PCTK1

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the CDK16 gene.

CDK16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTL
Identifiers
Aliases	CDK16, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1, cyclin-dependent kinase 16, cyclin dependent kinase 16
External IDs	OMIM: 311550; MGI: 97516; HomoloGene: 7878; GeneCards: CDK16; OMA:CDK16 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.3 Start 47,217,860 bp End 47,229,997 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.3|X 16.18 cM Start 20,554,193 bp End 20,566,119 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum muscle of thigh apex of heart gastrocnemius muscle right frontal lobe ganglionic eminence stromal cell of endometrium right auricle prefrontal cortex ventricular zone Top expressed in fossa condyle Paneth cell motor neuron ascending aorta aortic valve substantia nigra lobe of cerebellum cerebellar vermis internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding protein kinase activity kinase activity ATP binding transferase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity Cellular component microtubule cytoskeleton synapse cell junction membrane transport vesicle cytoplasmic vesicle neuron projection extrinsic component of cytoplasmic side of plasma membrane cytoplasm plasma membrane nucleus cytosol synaptic vesicle Biological process phosphorylation cell differentiation regulation of insulin secretion involved in cellular response to glucose stimulus protein phosphorylation growth hormone secretion spermatogenesis exocytosis neuron projection development regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5127 18555 Ensembl ENSG00000102225 ENSMUSG00000031065 UniProt Q00536 Q04735 RefSeq (mRNA) NM_001170460 NM_006201 NM_033018 NM_033019 NM_011049 NM_001310456 RefSeq (protein) NP_001163931 NP_006192 NP_148978 NP_001297385 NP_035179 Location (UCSC) Chr X: 47.22 – 47.23 Mb Chr X: 20.55 – 20.57 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.

Interactions

PCTK1 has been shown to interact with CDK5R1.

Further reading

• Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
• Knight JC, Renwick PJ, Downing JR, Okuda T (1995). "Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3". Cytogenet. Cell Genet. 71 (2): 155–7. doi:10.1159/000134097. PMID 7656587.
• Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
• Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB, Willard HF (1996). "X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse". Hum. Mol. Genet. 5 (3): 391–401. doi:10.1093/hmg/5.3.391. PMID 8852665.
• Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F (1997). "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins". Mol. Gen. Genet. 254 (5): 571–7. doi:10.1007/s004380050453. PMID 9197417. S2CID 22809140.
• Esposito T, Gianfrancesco F, Ciccodicola A, D'Esposito M, Nagaraja R, Mazzarella R, D'Urso M, Forabosco A (1997). "Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E". Genomics. 43 (2): 183–90. doi:10.1006/geno.1997.4797. PMID 9244435.
• Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. 273 (39): 25388–92. doi:10.1074/jbc.273.39.25388. PMID 9738006.
• Le Bouffant F, Capdevielle J, Guillemot JC, Sladeczek F (1998). "Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins". Eur. J. Biochem. 257 (1): 112–20. doi:10.1046/j.1432-1327.1998.2570112.x. PMID 9799109.
• Besset V, Rhee K, Wolgemuth DJ (1999). "The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation". Cell Growth Differ. 10 (3): 173–81. PMID 10099831.
• Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709.
• Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T (2002). "Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells" (PDF). J. Cell Sci. 115 (Pt 17): 3479–90. doi:10.1242/jcs.115.17.3479. PMID 12154078.
• Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F (2004). "Protein profile of tax-associated complexes". J. Biol. Chem. 279 (1): 495–508. doi:10.1074/jbc.M310069200. PMID 14530271.
• Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Liu Y, Cheng K, Gong K, Fu AK, Ip NY (2006). "Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis". J. Biol. Chem. 281 (15): 9852–8. doi:10.1074/jbc.M513496200. PMID 16461345.