CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase

In enzymology, a CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Identifiers
EC no.	2.7.8.5
CAS no.	9068-49-9
Alt. names	glycerophosphate phosphatidyltransferase 3-phosphatidyl-1'-glycerol-3'-phosphate synthase CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase phosphatidylglycerophosphate synthase phosphatidylglycerolphosphate synthase PGP synthase CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase glycerol phosphate phosphatidyltransferase glycerol 3-phosphate phosphatidyltransferase phosphatidylglycerol phosphate synthase phosphatidylglycerol phosphate synthetase phosphatidylglycerophosphate synthetase sn-glycerol-3-phosphate phosphatidyltransferase
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

CDP-diacylglycerol + sn-glycerol 3-phosphate $\rightleftharpoons$ CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate

Thus, the two substrates of this enzyme are CDP-diacylglycerol and sn-glycerol 3-phosphate, whereas its two products are CMP and 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. This enzyme participates in glycerophospholipid metabolism.

References

• Bleasdale JE, Johnston JM (1982). "CMP-dependent incorporation of [14C]Glycerol 3-phosphate into phosphatidylglycerol and phosphatidylglycerol phosphate by rabbit lung microsomes". Biochim. Biophys. Acta. 710 (3): 377–90. doi:10.1016/0005-2760(82)90121-7. PMID 7074121.
• Hirabayashi T, Larson TJ, Dowhan W (1976). "Membrane-associated phosphatidylglycerophosphate synthetase from Escherichia coli: purification by substrate affinity chromatography on cytidine 5'-diphospho-1,2-diacyl-sn-glycerol sepharose". Biochemistry. 15 (24): 5205–11. doi:10.1021/bi00669a002. PMID 793612.