CDw17 antigen is a lactosylceramide,[1] a class of glycosphingolipids found in microdomains on the plasma layers of numerous cells. It is found on human neutrophils, basophils, monocyte, platelets, tonsillar CD45+ dendritic cells, epithelial cells, endothelial cells in intestinal epithelium, and on post-proliferative granulocytes in the bone marrow. [2]
CDw17 acts as a precursor for biosynthesis of glycosphingolipids.[3]
The enzyme A4GALT acts upon it, aiding transfer of galactose to lactosylceramide to form globotriaosylceramide.
References
edit- ^ CDw17+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ Barclay AN, Brown MH, Law SK, McKnight AJ, Tomlinson MG, van der Merwe PA (1997). "CDw17". In Barclay AN (ed.). The Leucocyte Antigen Factsbook. Factsbook Series (2nd ed.). San Diego: Academic Press. p. 176. doi:10.1016/B978-012078185-0/50452-2. ISBN 978-0-12-078185-0.
- ^ Chatterjee S, Balram A, Li W (February 2021). "Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes". International Journal of Molecular Sciences. 22 (4): 1816. doi:10.3390/ijms22041816. PMC 7917694. PMID 33673027.
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