CUGBP Elav-like family member 4

CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.

CELF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGP, 2DNK
Identifiers
Aliases	CELF4, BRUNOL-4, BRUNOL4, CELF-4, CUGBP, Elav-like family member 4, CUGBP Elav-like family member 4
External IDs	OMIM: 612679; MGI: 1932407; HomoloGene: 23202; GeneCards: CELF4; OMA:CELF4 - orthologs
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A2 Start 25,477,632 bp End 25,754,157 bp
Gene ontology Molecular function RNA binding BRE binding mRNA binding nucleic acid binding translation repressor activity, mRNA regulatory element binding pre-mRNA binding Cellular component cytoplasm nucleus ribonucleoprotein complex Biological process germ cell development mRNA processing negative regulation of mRNA splicing, via spliceosome alternative mRNA splicing, via spliceosome mRNA splice site selection regulation of alternative mRNA splicing, via spliceosome negative regulation of excitatory postsynaptic potential RNA splicing positive regulation of mRNA splicing, via spliceosome negative regulation of translation regulation of retina development in camera-type eye embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56853 108013 Ensembl ENSG00000101489 ENSMUSG00000024268 UniProt Q9BZC1 Q7TSY6 RefSeq (mRNA) NM_001025087 NM_001025088 NM_001025089 NM_020180 NM_001330603 NM_001146292 NM_001146293 NM_001146294 NM_001146295 NM_001174074 NM_133195 RefSeq (protein) NP_001020258 NP_001020259 NP_001020260 NP_001317532 NP_064565 NP_001340624 NP_001340625 NP_001340626 NP_001340627 NP_001340628 NP_001340629 NP_001340630 NP_001340631 NP_001340632 NP_001340634 NP_001340635 NP_001340637 NP_001340638 NP_001340639 NP_001340640 NP_001340641 NP_001340642 NP_001340643 NP_001340644 NP_001340645 NP_001340646 NP_001340647 NP_001340648 NP_001340649 NP_001340650 NP_001340651 NP_001340652 NP_001340653 NP_001340654 NP_001340655 NP_001340656 NP_001340657 NP_001340658 NP_001340659 NP_001340660 NP_001340661 NP_001340662 NP_001340663 NP_001340664 NP_001340665 NP_001340666 NP_001340667 NP_001340668 NP_001340669 NP_001340670 NP_001340671 NP_001340672 NP_001340673 NP_001340674 NP_001340675 NP_001340676 NP_001340677 NP_001340678 NP_001340679 NP_001340680 NP_001340681 NP_001340682 NP_001340683 NP_001340684 NP_001340685 NP_001340686 NP_001340687 NP_001340688 NP_001340689 NP_001340690 NP_001340636 NP_001139764 NP_001139765 NP_001139766 NP_001167545 NP_573458 NP_001349204 NP_001349205 NP_001349206 NP_001349207 NP_001349208 NP_001349209 NP_001349210 NP_001349211 NP_001349212 NP_001349213 NP_001349214 NP_001349215 NP_001349217 NP_001349218 NP_001349219 NP_001349220 NP_001349221 NP_001349222 NP_001349223 NP_001349224 NP_001349226 NP_001349228 NP_001349229 NP_001349230 NP_001349231 NP_001349232 NP_001349237 NP_001349238 NP_001349239 NP_001349240 NP_001349242 NP_001349244 NP_001349245 NP_001349252 NP_001349253 NP_001349254 NP_001349255 NP_001349256 NP_001349257 NP_001349258 NP_001349259 NP_001349260 NP_001349261 NP_001349263 NP_001349264 NP_001349265 NP_001349266 NP_001349233 NP_001349251 Location (UCSC) n/a Chr 18: 25.48 – 25.75 Mb PubMed search
Wikidata
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Function

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.

External links

• Human CELF4 genome location and CELF4 gene details page in the UCSC Genome Browser.

Further reading

• Szafranski K, Schindler S, Taudien S, et al. (2008). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
• Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
• Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
• Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
• Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.