CGN may refer to:
- CGN, a gene that encodes for the protein cingulin
- Ceredigion, formerly Cardiganshire, historic county in Wales, Chapman code
- China General Nuclear Power Group, a Chinese energy company
- Compagnie Générale de Navigation sur le lac Léman, a Swiss company operating boats on Lake Léman
- Childhood gender nonconformity, a childhood behavioral pattern
- CGN, IATA code for Cologne Bonn Airport, Germany
- CGN, National Rail station code for Cogan railway station, Wales
- CGN, U.S. Navy designation for a nuclear-powered guided missile cruiser
- Carrier-grade NAT, an approach to IPv4 network design where end sites are configured with private network addresses
- CGN, cis Golgi network, compartment of the Golgi apparatus
- Crescentic glomerulonephritis, a syndrome of the kidney that is characterized by a rapid loss of kidney function