Chimerin 2

Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the CHN2 gene.

CHN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XA6
Identifiers
Aliases	CHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3, chimerin 2
External IDs	OMIM: 602857; MGI: 1917243; HomoloGene: 31213; GeneCards: CHN2; OMA:CHN2 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B3 Start 54,016,539 bp End 54,278,795 bp
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in lobe of cerebellum cerebellar vermis seminiferous tubule olfactory tubercle spermatid zygote nucleus accumbens lateral septal nucleus pontine nuclei interventricular septum BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component cytoplasm cytosol membrane Biological process intracellular signal transduction regulation of small GTPase mediated signal transduction signal transduction positive regulation of signal transduction positive regulation of GTPase activity regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1124 69993 Ensembl ENSG00000106069 ENSMUSG00000004633 UniProt P52757 Q80XD1 RefSeq (mRNA) NM_001039936 NM_001293069 NM_001293070 NM_001293071 NM_001293072 NM_001293073 NM_001293075 NM_001293076 NM_001293077 NM_001293078 NM_001293079 NM_001293080 NM_001293081 NM_004067 NM_001398427 NM_001163640 NM_023543 NM_001311133 NM_001311134 RefSeq (protein) NP_001035025 NP_001279998 NP_001279999 NP_001280000 NP_001280001 NP_001280002 NP_001280004 NP_001280005 NP_001280006 NP_001280007 NP_001280008 NP_001280009 NP_001280010 NP_004058 NP_001157112 NP_001298062 NP_001298063 NP_076032 Location (UCSC) n/a Chr 6: 54.02 – 54.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/diacylglycerol-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Yuan S, Miller DW, Barnett GH, et al. (1995). "Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma". Cancer Res. 55 (15): 3456–61. PMID 7614486.
• Caloca MJ, Fernandez N, Lewin NE, et al. (1997). "Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters". J. Biol. Chem. 272 (42): 26488–96. doi:10.1074/jbc.272.42.26488. PMID 9334226.
• Caloca MJ, Garcia-Bermejo ML, Blumberg PM, et al. (1999). "beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11854–9. Bibcode:1999PNAS...9611854J. doi:10.1073/pnas.96.21.11854. PMC 18376. PMID 10518540.
• Caloca MJ, Wang H, Delemos A, et al. (2001). "Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor". J. Biol. Chem. 276 (21): 18303–12. doi:10.1074/jbc.M011368200. PMID 11278894.
• Wang H, Kazanietz MG (2002). "Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain". J. Biol. Chem. 277 (6): 4541–50. doi:10.1074/jbc.M107150200. PMID 11689559.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Nishiu M, Yanagawa R, Nakatsuka S, et al. (2003). "Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression". Jpn. J. Cancer Res. 93 (8): 894–901. doi:10.1111/j.1349-7006.2002.tb01335.x. PMC 5927108. PMID 12716467.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Caloca MJ, Wang H, Kazanietz MG (2004). "Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor". Biochem. J. 375 (Pt 2): 313–21. doi:10.1042/BJ20030727. PMC 1223697. PMID 12877655.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Canagarajah B, Leskow FC, Ho JY, et al. (2004). "Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin". Cell. 119 (3): 407–18. doi:10.1016/j.cell.2004.10.012. PMID 15507211. S2CID 10076951.
• Hashimoto R, Yoshida M, Kunugi H, et al. (2005). "A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men". Schizophrenia Research. 73 (2–3): 383–5. doi:10.1016/j.schres.2004.01.017. PMID 15653288. S2CID 36432346.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Yang C, Liu Y, Leskow FC, et al. (2005). "Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin". J. Biol. Chem. 280 (26): 24363–70. doi:10.1074/jbc.M411629200. PMID 15863513.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Siliceo M, García-Bernal D, Carrasco S, et al. (2006). "Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells" (PDF). J. Cell Sci. 119 (Pt 1): 141–52. doi:10.1242/jcs.02722. hdl:10261/72248. PMID 16352660. S2CID 19107302.
• Yang C, Liu Y, Lemmon MA, Kazanietz MG (2006). "Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4". Mol. Cell. Biol. 26 (3): 831–42. doi:10.1128/MCB.26.3.831-842.2006. PMC 1347034. PMID 16428439.