Carboxypeptidase A1

Carboxypeptidase A1 is an enzyme that in humans is encoded by the CPA1 gene.

CPA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V77, 3FJU, 4UEZ, 4UF4, 4UEE, 4UEF
Identifiers
Aliases	CPA1, CPA, carboxypeptidase A1
External IDs	OMIM: 114850; MGI: 88478; HomoloGene: 55609; GeneCards: CPA1; OMA:CPA1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q32.2 Start 130,380,339 bp End 130,388,114 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 A3.3|6 12.52 cM Start 30,639,217 bp End 30,645,362 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans beta cell testicle ectocervix right coronary artery right lobe of liver left uterine tube canal of the cervix right uterine tube Top expressed in pyloric antrum islet of Langerhans secondary oocyte primary oocyte zygote migratory enteric neural crest cell duodenum embryo sexually immature organism Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxypeptidase activity zinc ion binding peptidase activity exopeptidase activity hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity protein binding Cellular component extracellular region extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1357 109697 Ensembl ENSG00000091704 ENSMUSG00000054446 UniProt P15085 Q7TPZ8 RefSeq (mRNA) NM_001868 NM_025350 RefSeq (protein) NP_001859 NP_079626 Location (UCSC) Chr 7: 130.38 – 130.39 Mb Chr 6: 30.64 – 30.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition.

Further reading

• Catasús L, Villegas V, Pascual R, et al. (1992). "cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1". Biochem. J. 287 (1): 299–303. doi:10.1042/bj2870299. PMC 1133158. PMID 1417781.
• Stewart EA, Craik CS, Hake L, Bowcock AM (1990). "Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter". Am. J. Hum. Genet. 46 (4): 795–800. PMC 1683655. PMID 1969228.
• Moulard M, Michon T, Kerfelec B, Chapus C (1990). "Further studies on the human pancreatic binary complexes involving procarboxypeptidase A." FEBS Lett. 261 (1): 179–83. doi:10.1016/0014-5793(90)80665-6. PMID 2307232. S2CID 6705621.
• Pascual R, Burgos FJ, Salva M, et al. (1989). "Purification and properties of five different forms of human procarboxypeptidases". Eur. J. Biochem. 179 (3): 609–16. doi:10.1111/j.1432-1033.1989.tb14590.x. PMID 2920728.
• Honey NK, Sakaguchi AY, Lalley PA, et al. (1986). "Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6". Hum. Genet. 72 (1): 27–31. doi:10.1007/BF00278813. PMID 3455919. S2CID 38300147.
• Velculescu VE, Zhang L, Vogelstein B, Kinzler KW (1995). "Serial analysis of gene expression". Science. 270 (5235): 484–7. Bibcode:1995Sci...270..484V. doi:10.1126/science.270.5235.484. PMID 7570003. S2CID 16281846.
• Laethem RM, Blumenkopf TA, Cory M, et al. (1996). "Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2". Arch. Biochem. Biophys. 332 (1): 8–18. doi:10.1006/abbi.1996.0310. PMID 8806703.
• Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry. 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156. S2CID 13282515.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• The MEROPS online database for peptidases and their inhibitors: M14.001
• Overview of all the structural information available in the PDB for UniProt: P15085 (Carboxypeptidase A1) at the PDBe-KB.