Capping protein (actin filament) muscle Z-line, alpha 1

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.

CAPZA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ1, 1MWN
Identifiers
Aliases	CAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1, capping actin protein of muscle Z-line subunit alpha 1
External IDs	OMIM: 601580; MGI: 106227; HomoloGene: 24376; GeneCards: CAPZA1; OMA:CAPZA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.2 Start 112,619,805 bp End 112,671,616 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F2.2|3 45.88 cM Start 104,730,095 bp End 104,771,821 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx gingival epithelium bone marrow germinal epithelium mucosa of pharynx monocyte trabecular bone skin of thigh oral cavity bone marrow cells Top expressed in granulocyte tail of embryo thymus spermatocyte yolk sac genital tubercle ventricular zone ileum stomach neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding cadherin binding actin filament binding Cellular component F-actin capping protein complex cytoplasm extracellular region cytosol WASH complex extracellular exosome cytoskeleton actin cytoskeleton actin cortical patch Biological process barbed-end actin filament capping innate immune response blood coagulation actin filament capping endoplasmic reticulum to Golgi vesicle-mediated transport antigen processing and presentation of exogenous peptide antigen via MHC class II interleukin-12-mediated signaling pathway cell junction assembly actin cytoskeleton organization protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 829 12340 Ensembl ENSG00000116489 ENSMUSG00000070372 UniProt P52907 P47753 RefSeq (mRNA) NM_006135 NM_009797 NM_001355044 RefSeq (protein) NP_006126 NP_033927 NP_001341973 Location (UCSC) Chr 1: 112.62 – 112.67 Mb Chr 3: 104.73 – 104.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring. This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Maun NA, Speicher DW, DiNubile MJ, Southwick FS (1996). "Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes". Biochemistry. 35 (11): 3518–24. doi:10.1021/bi952470p. PMID 8639502.
• Hart MC, Korshunova YO, Cooper JA (1997). "Vertebrates have conserved capping protein alpha isoforms with specific expression patterns". Cell Motil. Cytoskeleton. 38 (2): 120–32. doi:10.1002/(SICI)1097-0169(1997)38:2<120::AID-CM2>3.0.CO;2-B. PMID 9331217.
• Kuhlman PA, Fowler VM (1997). "Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin". Biochemistry. 36 (44): 13461–72. doi:10.1021/bi970601b. PMID 9354614.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Osterloh D, Ivanenkov VV, Gerke V (1999). "Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization". Cell Calcium. 24 (2): 137–51. doi:10.1016/S0143-4160(98)90081-1. PMID 9803314.
• Inman KG, Yang R, Rustandi RR, et al. (2003). "Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12". J. Mol. Biol. 324 (5): 1003–14. doi:10.1016/S0022-2836(02)01152-X. PMID 12470955.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• McClintock KA, Shaw GS (2003). "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex". J. Biol. Chem. 278 (8): 6251–7. doi:10.1074/jbc.M210622200. PMID 12480931.
• Taoka M, Ichimura T, Wakamiya-Tsuruta A, et al. (2003). "V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein". J. Biol. Chem. 278 (8): 5864–70. doi:10.1074/jbc.M211509200. PMID 12488317.
• Hutchings NJ, Clarkson N, Chalkley R, et al. (2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85". J. Biol. Chem. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Canton DA, Olsten ME, Niederstrasser H, et al. (2007). "The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein". J. Biol. Chem. 281 (47): 36347–59. doi:10.1074/jbc.M607595200. PMC 2583070. PMID 16987810.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.