Rubidium-82 chloride is a form of rubidium chloride containing a radioactive isotope of rubidium. It is marketed under the brand name Cardiogen-82 by Bracco Diagnostics for use in Myocardial perfusion imaging.[1] It is rapidly taken up by heart muscle cells, and therefore can be used to identify regions of heart muscle that are receiving poor blood flow in a technique called PET perfusion imaging.[2] The half-life of rubidium-82 is only 1.27 minutes; it is normally produced at the place of use by rubidium generators.[3]
| Names | |
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| IUPAC name
Rubidium-82 chloride
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| Systematic IUPAC name
(82Rb)Rubidium chloride | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| KEGG | |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| ClRb | |
| Molar mass | 117.371 g mol−1 |
| Pharmacology | |
| V09GX04 (WHO) | |
| Related compounds | |
Other cations
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Caesium chloride Lithium chloride |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ^ Wackers, Frans J. Th.; Bruni, Wendy; Zaret, Barry L. (2007-11-19). "Rubidium-82 Generator". Nuclear cardiology: the basics: how to set up and maintain a laboratory. Springer. ISBN 978-1-58829-924-6.
- ^ Ballinger, James R. (2009). "PET Radiopharmaceuticals in Nuclear Cardiology: Current Status and Limitations". Integrating Cardiology for Nuclear Medicine Physicians. pp. 379–385. doi:10.1007/978-3-540-78674-0_32. ISBN 978-3-540-78673-3.
- ^ Gould, K. Lance; Goldstein, Richard A.; Mullani, Nizar A.; Kirkeeide, Richard L.; Wong, Wai-Hoi; Tewson, Timothy J.; Berridge, Marc S.; Bolomey, Leonard A.; Hartz, Ross K.; Smalling, Richard W.; Fuentes, Francisco; Nishikawa, Akira (1986). "Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced Rubidium-82". Journal of the American College of Cardiology. 7 (4): 775–789. doi:10.1016/S0735-1097(86)80336-9. PMID 3485669.
Further reading
edit- Clarke, Michael J; Sadler, P. J (1999-06-15). Metallopharmaceuticals: Diagnosis and therapy. Springer. ISBN 978-3-540-65308-0. (Note: only about 1/2 page on Rb-generator)
- Alvarez-Diez, T; Dekemp, R; Beanlands, R; Vincent, J (1999). "Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography". Applied Radiation and Isotopes. 50 (6): 1015–23. doi:10.1016/S0969-8043(98)00170-5. PMID 10355104.
- Waters, S. L.; Coursey, B. M., eds. (1987). "The Strontium-82/rubidium-82 generator". International Journal of Radiation Applications and Instrumentation A. 38 (3): 171–239.
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