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Farmitalia was an Italian pharmaceutical company best known for its parallel discovery with Rhone-Poulenc of daunorubicin and subsequent discovery of doxorubicin.[1] Farmitalia had been founded in 1935 as a joint venture by Rhone-Poulenc and Montecatini.[2] Farmitalia occupied a position of choice in the world rankings of the profession, not only in Italy, but also at the world level with in particular the patent of Adriamycin, an anti-cancer drug qualified. From its creation, Farmaceutici Italia buys the Schiapparelli factory.[3]
| Industry | Pharmaceutical |
|---|---|
| Founded | 1935 |
In 1978, Farmitalia was merged with Carlo Erba SpA, an Italian pharmaceutical company that had been founded in 1853 by the pharmacist Carlo Erba, in which Montecatini had acquired a controlling interest in 1971. The merged company was called Farmitalia Carlo Erba SpA.[2]
Farmitalia Carlo Erba was acquired by Pharmacia in 1993,[4] then Pharmacia was acquired by Pfizer in 2003.[5]
Drugs discovered at Farmitalia that reached the market included (with date of first publication):
- 1960 Sulfalene[6][7]
- 1963 Daunorubicin[8][9]
- 1969 Doxorubicin[1][10]
- 1980 Cabergoline[11][12]
- 1984 Reboxetine[13][14]
References
edit- ^ a b Weiss RB (December 1992). "The anthracyclines: will we ever find a better doxorubicin?". Seminars in Oncology. 19 (6): 670–86. PMID 1462166.
- ^ a b Bilotto, Antonella. "Carlo Erba SpA". LombardiaBeniCulturali. Retrieved 9 May 2017.
- ^ http://admin (2019-04-17). "SETTIMO. La Farmitalia, storia di un'industria". Giornale La Voce (in Italian). Retrieved 2022-07-25.
- ^ Staff. News: Farmitalia bought by Kabi Pharmacia[permanent dead link]. Ann Oncol (1993) 4 (5): 345.
- ^ Staff, CNN/Money. April 16, 2003 It's official: Pfizer buys Pharmacia
- ^ Baruffa, G (1966). "Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide". Trans R Soc Trop Med Hyg. 60 (2): 222–4. doi:10.1016/0035-9203(66)90030-7. PMID 5332105.
- ^ Per prior citation, the first publication: Camerino, B; Palamidessi, G (1960). "Derivati della parazina II. Sulfonamdopir (in Italian)". Gazz Chim Ital. 90: 1802–1815.
- ^ Suarato, A; Angelucci, F; Geroni, C (Mar 1999). "Ring-B modified anthracyclines". Curr Pharm Des. 5 (3): 217–27. doi:10.2174/1381612805666230109215627. PMID 10066891.
- ^ Grein A, et al. Descrizione e classificazione di un attinomicete (Streptonryces peucetius sp. nova) produttore di una sostanza ad attivita antitumorale. Giorn. Microbiol. 11: 109~ 118, 1963
- ^ Arcamone F, Cassinelli G, Fantini G, et al. (1969). "Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius". Biotechnol Bioeng. 11 (6): 1101–10. doi:10.1002/bit.260110607. PMID 5365804. S2CID 21897153.
- ^ Council regulation (EEC) no 1768/92 in the matter of Application No SPC/GB94/012 for a Supplementary Protection Certificate in the name of Farmitalia Carlo Erba S. r. l.
- ^ Espace record: GB 202074566
- ^ Cocchiara, G; et al. (1991). "Comparison of the disposition and of the metabolic pattern of Reboxetine, a new antidepressant, in the rat, dog, monkey and man". Eur J Drug Metab Pharmacokinet. 16 (3): 231–9. doi:10.1007/bf03189965. PMID 1814741. S2CID 874781.
- ^ First publication per prior citation: Melloni, M; et al. (1984). "Potential antidepressant agents. α-aryloxy-benzyl derivatives of ethanolamine and morpholine". Eur J Med Chem. 3: 235–242.