There are two variants of the receptor, each encoded by a separate gene:
CD120a - TNFR1 - TNFR superfamily member 1A
CD120b - TNFR2 - TNFR superfamily member 1B TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[ 3] [ 4] [ 5]
Signaling pathway of TNF -R1. Dashed grey lines represent multiple steps
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