CD151

CD151
Identifiers
Aliases	CD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group), EBS7
External IDs	OMIM: 602243; MGI: 1096360; HomoloGene: 20916; GeneCards: CD151; OMA:CD151 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	839,831 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,051,386 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; stromal cell of endometrium; ; apex of heart; ; body of pancreas; ; upper lobe of left lung;
	Top expressed in
	endothelial cell of lymphatic vessel; ; medullary collecting duct; ; Paneth cell; ; renal corpuscle; ; iris; ; tunica media of zone of aorta; ; carotid body; ; tunica adventitia of aorta; ; ciliary body; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; protein binding;
Cellular component	cytosol; membrane; focal adhesion; basement membrane; integral component of membrane; integral component of plasma membrane; plasma membrane; cell surface;
Biological process	cell adhesion; cell surface receptor signaling pathway; hemidesmosome assembly; T cell proliferation; cell migration; positive regulation of cell migration; wound healing, spreading of cells; positive regulation of endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	977
	12476
	ENSG00000177697
	ENSMUSG00000025510
	P48509; Q6ZNZ0
	O35566
	NM_139030; NM_001039490; NM_004357; NM_139029
	NM_001111049; NM_001111050; NM_009842
NP_001034579; NP_004348; NP_620598; NP_620599; NP_001034579.1;
	NP_004348.2; NP_620598.1; NP_620599.1
	NP_001104519; NP_001104520; NP_033972
	Wikidata
View/Edit Human	View/Edit Mouse

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.^[5]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.^[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.^[6]^[7]

Interactions

Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025510 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD151 CD151 molecule (Raph blood group)".
^ Bardhan A, Bruckner-Tuderman L, Chapple IL, Fine JD, Harper N, Has C, et al. (September 2020). "Epidermolysis bullosa". Nature Reviews. Disease Primers. 6 (1): 78. doi:10.1038/s41572-020-0210-0. PMID 32973163. S2CID 221861310.
^ Vahidnezhad H, Youssefian L, Saeidian AH, Mahmoudi H, Touati A, Abiri M, et al. (March 2018). "Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy". Matrix Biology. 66: 22–33. doi:10.1016/j.matbio.2017.11.003. hdl:11573/1182681. PMID 29138120. S2CID 3812225.
^ Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, et al. (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". European Journal of Immunology. 30 (3): 900–907. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–4151. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Ashman LK (2003). "CD151". Journal of Biological Regulators and Homeostatic Agents. 16 (3): 223–226. PMID 12456024.
Ashman LK, Aylett GW, Mehrabani PA, Bendall LJ, Niutta S, Cambareri AC, et al. (October 1991). "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen". British Journal of Haematology. 79 (2): 263–270. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID 1958484. S2CID 6682391.
Fitter S, Tetaz TJ, Berndt MC, Ashman LK (August 1995). "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood. 86 (4): 1348–1355. doi:10.1182/blood.V86.4.1348.bloodjournal8641348. hdl:2440/103301. PMID 7632941.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hasegawa H, Utsunomiya Y, Kishimoto K, Yanagisawa K, Fujita S (May 1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily". Journal of Virology. 70 (5): 3258–3263. doi:10.1128/JVI.70.5.3258-3263.1996. PMC 190191. PMID 8627808.
Hasegawa H, Kishimoto K, Yanagisawa K, Terasaki H, Shimadzu M, Fujita S (February 1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization". Genomics. 40 (1): 193–196. doi:10.1006/geno.1996.4563. PMID 9070943.
Sincock PM, Mayrhofer G, Ashman LK (April 1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". The Journal of Histochemistry and Cytochemistry. 45 (4): 515–525. doi:10.1177/002215549704500404. PMID 9111230.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fitter S, Seldin MF, Ashman LK (May 1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1398 (1): 75–85. doi:10.1016/S0167-4781(98)00034-7. PMID 9602068.
Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK (March 1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". Journal of Cell Science. 112 ( Pt 6) (6): 833–844. doi:10.1242/jcs.112.6.833. hdl:2440/8940. PMID 10036233.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, et al. (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (Pt 1): 103–111. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
Testa JE, Brooks PC, Lin JM, Quigley JP (August 1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Research. 59 (15): 3812–3820. PMID 10447000.
Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A (May 2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes". The Journal of Cell Biology. 149 (4): 969–982. doi:10.1083/jcb.149.4.969. PMC 2174566. PMID 10811835.
Whittock NV, McLean WH (February 2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochemical and Biophysical Research Communications. 281 (2): 425–430. doi:10.1006/bbrc.2001.4384. PMID 11181065.
Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, et al. (April 2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". The Journal of Biological Chemistry. 276 (17): 14329–14337. doi:10.1074/jbc.M011297200. PMID 11278880.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, et al. (May 2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Research. 11 (5): 677–684. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (January 2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". International Journal of Cancer. 97 (3): 336–343. doi:10.1002/ijc.1605. PMID 11774285. S2CID 46569418.
Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME (January 2002). "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis". Molecular Biology of the Cell. 13 (1): 1–11. doi:10.1091/mbc.01-10-0481. PMC 65068. PMID 11809818.

External links

Raph blood group system in the BGMUT blood group antigen gene mutation database
Human CD151 genome location and CD151 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177697 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025510 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD151 CD151 molecule (Raph blood group)".

[6] Bardhan A, Bruckner-Tuderman L, Chapple IL, Fine JD, Harper N, Has C, et al. (September 2020). "Epidermolysis bullosa". Nature Reviews. Disease Primers. 6 (1): 78. doi:10.1038/s41572-020-0210-0. PMID 32973163. S2CID 221861310.

[7] Vahidnezhad H, Youssefian L, Saeidian AH, Mahmoudi H, Touati A, Abiri M, et al. (March 2018). "Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy". Matrix Biology. 66: 22–33. doi:10.1016/j.matbio.2017.11.003. hdl:11573/1182681. PMID 29138120. S2CID 3812225.

[pmid10741407-8] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, et al. (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". European Journal of Immunology. 30 (3): 900–907. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

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CD151

Contents

Function

Interactions

See also

References

Further reading

External links