Charles Stein may refer to:
- Charles Stein (athlete) (1911-1981), Luxembourgian Olympic runner
- Charles Stein (statistician) (1920-2016), American statistician
- Charles F. Stein (1900–1979), Baltimore historian and heraldist
- Charles Francis Stein, Sr. (1866–1939), Baltimore city judge
- Charles Ramsay Stirling Stein (1897–?), Canadian Army officer
- Charles-Adolphe Stein (1878–1938), Quebec politician, lawyer and judge