Charles Weber may refer to:
- Charles Maria Weber, founder of Stockton, California
- Charles Weber (baseball), general manager of the Chicago Cubs
- Chuck Weber (American football) (1930–2017), former American football linebacker
- Chuck Weber (ice hockey) (born 1973), American ice hockey coach
- Chuck Weber (racing driver) (born 1958), American stock car driver
- Chuck Weber (politician), American politician and member of the Kansas House of Representatives
- Charles H. Weber (Chuck Weber), state legislator in Florida who served in the Florida Senate