Charles Willis may refer to:
- Charles Willis (cricketer) (1827–1895), English amateur cricketer
- Charles T. Willis (1841–1921), New York politician
- Charles Willis, pseudonym of Arthur C. Clarke (1917-2008), British science and science fiction author
- Charles F. Willis (1918–1993), assistant to Dwight D. Eisenhower
- Charles Willis, one of The Willis Brothers, a country music ensemble