Pseudoephedrine/loratadine, sold under the brand name Claritin-D among others, is an orally administered combination drug used for the treatment of allergic rhinitis (hay fever) and the common cold.[1] Pseudoephedrine, one of the naturally occurring alkaloids of ephedra, is a sympathomimetic used as a decongestant.[medical citation needed] It produces a decongestant effect that is facilitated by the vasoconstriction in the mucosal capillaries of the upper respiratory areas.[medical citation needed] Loratadine is a long-acting antihistamine (H1 histamine antagonist) that is less sedating than older substances of its type.[medical citation needed]
| Combination of | |
|---|---|
| Pseudoephedrine | Sympathomimetic |
| Loratadine | H1 antagonist |
| Clinical data | |
| Trade names | Claritin-D, others |
| AHFS/Drugs.com | claritin-d |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
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Medical uses
editPseudoephedrine/loratadine are indicated for the relief of symptoms associated with allergic rhinitis and the common cold including nasal congestion, sneezing, rhinorrhea, pruritus, and lacrimation.[1][2]
Composition
editClarinase Repetabs
editA Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.
Interactions, adverse effects and contraindications
editInteractions, adverse effects and contraindications are described in more detail in the articles about pseudoephedrine and loratadine.
Interactions
editWhen sympathomimetics are given to patients receiving monoamine oxidase inhibitors (MAO inhibitors), hypertensive reactions, including hypertensive crises may occur.
Adverse effects
editDuring controlled clinical studies with the recommended dosage, the incidence of adverse effects was comparable to that of placebo, with the exception of insomnia and dry mouth, both of which were commonly reported.
Contraindications
editPseudoephedrine/loratadine is contraindicated in people receiving MAO inhibitor therapy or within 14 days of discontinuing such treatment and in people with narrow angle glaucoma, urinary retention, severe hypertension, severe coronary artery disease and hyperthyroidism.
Society and culture
editBrand names
editIt is sold under various brand names including Claritin-D, Clarinase, Clarinase Repetabs, Lorinase, Rhinos SR, and Allerclear-D.
References
edit- ^ a b c "Claritin-D 12 hour- loratadine and pseudoephedrine sulfate tablet, extended release". DailyMed. 30 November 2023. Retrieved 8 July 2024.
- ^ Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Clarinase 5 mg/120 mg Retardtabletten. ISBN 978-3-85200-196-8.
