Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

CLDN4
Identifiers
AliasesCLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, claudin 4
External IDsOMIM: 602909; MGI: 1313314; HomoloGene: 1000; GeneCards: CLDN4; OMA:CLDN4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001305

NM_009903

RefSeq (protein)

NP_001296

NP_034033

Location (UCSC)Chr 7: 73.8 – 73.83 MbChr 5: 134.97 – 134.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.[5]

Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma.[6] As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189143Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047501Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CLDN4 claudin 4".
  6. ^ Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma". Int J Surg Pathol. 21 (5): 493–501. doi:10.1177/1066896913491320. PMID 23775021. S2CID 6840615.
  7. ^ Vojtek M, Walsh MD, Papadimos DJ, Shield PW (2019). "Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens" (PDF). Cytopathology. 30 (6): 614–619. doi:10.1111/cyt.12765. PMID 31390089. S2CID 199468828.
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Further reading

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