Clidinium bromide

Clidinium bromide
Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a601036
Routes of; administration	Oral
ATC code	A03CA02 (WHO) (combination with psycholeptics);
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	Low
Excretion	Renal and biliary
Identifiers
	IUPAC name 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide;
CAS Number	7020-55-5 3485-62-9;
PubChem CID	2784;
IUPHAR/BPS	366;
DrugBank	DB00771 ;
ChemSpider	2682 ;
UNII	BO76JF850N;
KEGG	D00716;
ChEMBL	ChEMBL1200950 ;
CompTox Dashboard (EPA)	DTXSID6045379 ;
Chemical and physical data
Formula	C22H26NO3+
Molar mass	352.454 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4;
	InChI InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1 ; Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N ;
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Clidinium bromide (INN) is an anticholinergic (specifically a muscarinic antagonist) drug.^[1]^[2] It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. It is commonly prescribed in combination with chlordiazepoxide (a benzodiazepine derivative) using the brand name Librax,Normaxin CC.

Uses

Peptic ulcer disease

Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.^[3]

With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.

GI motility disturbances

Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome).

Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.

Acute enterocolitis

Used in fixed combination with chlordiazepoxide in the treatment of acute enterocolitis. However, antimuscarinics should be used with extreme caution in patients with diarrhea or ulcerative colitis.

Mechanism of action

Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions.^[4] It is said to be a selective muscarinic acetylcholine M₃ receptor antagonist.^[5]

References

^ "Clidinium bromide". Drugs.com. Retrieved August 24, 2013.
^ Aronson JK (2016). "Clidinium bromide". Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions (Sixteenth ed.). Amsterdam: Elsevier. p. 404. ISBN 978-0-444-53716-4.
^ "Clidinium Bromide Monograph". Drugs.com. Retrieved August 24, 2013.
^ "Clidinium bromide". 2014 Nurse's Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246. ISBN 978-1-284-03115-7.
^ Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM (January 2023). "A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity". Pharmaceutics. 15 (1): 230. doi:10.3390/pharmaceutics15010230. PMC 9863833. PMID 36678858.

External links

[1] "Clidinium bromide". Drugs.com. Retrieved August 24, 2013.

[Aronson_2016-2] Aronson JK (2016). "Clidinium bromide". Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions (Sixteenth ed.). Amsterdam: Elsevier. p. 404. ISBN 978-0-444-53716-4.

[3] "Clidinium Bromide Monograph". Drugs.com. Retrieved August 24, 2013.

[jones_and_bartlett-4] "Clidinium bromide". 2014 Nurse's Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246. ISBN 978-1-284-03115-7.

[LavradorCabralVeríssimo2023-5] Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM (January 2023). "A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity". Pharmaceutics. 15 (1): 230. doi:10.3390/pharmaceutics15010230. PMC 9863833. PMID 36678858.

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