Clocental

Clocental
Clinical data
Other names	Dolcental
Identifiers
	IUPAC name (1-Ethynylcyclohexyl) N-carbamoylcarbamate;
CAS Number	562-94-7 ;
PubChem CID	11231;
ChemSpider	10757 ;
UNII	UX2C2JZD57;
CompTox Dashboard (EPA)	DTXSID80204741 ;
Chemical and physical data
Formula	C10H14N2O3
Molar mass	210.233 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C#CC1(CCCCC1)OC(=O)NC(=O)N;
	InChI InChI=1S/C10H14N2O3/c1-2-10(6-4-3-5-7-10)15-9(14)12-8(11)13/h1H,3-7H2,(H3,11,12,13,14) ; Key:CQVLNDZXTPGTFD-UHFFFAOYSA-N ;

Clocental (dolcental) is a carbamate-derived sedative hypnotic.^[1]^[2]

Synthesis

Clocental was first prepared by the acylation of 1-ethynylcyclohexanol with allophanyl chloride.^[3]

^ Keil W, Muschaweck R, Rademacher E (August 1954). "[Sedative and hypnotic effect of the 1-ethinyl-cyclohexyl-allophante-(1)]". Arzneimittel-Forschung (in German). 4 (8): 477–479. PMID 13198744.
^ Preuss R, Kopp R (April 1959). "[Analysis of the renal excretion products of 1-ethinyl-cyclohexylacarbamate (valamine) & 1-ethinyl-cyclohexyl-allophanate (dolcental)]". Arzneimittel-Forschung (in German). 9 (4): 255–262. PMID 13651050.
^ US patent 2822379, Grimme W, Emde H, "Allophanates of alpha-ethynylcarbinols", issued 1958-02-04, assigned to Rheinpreussen AG fuer Bergbau und Chemie

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