Compound 48/80 is a polymer produced by the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.[1] It promotes histamine release,[2] and in biochemical research, compound 48/80 is used to promote mast cell degranulation.[3]
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| Names | |
|---|---|
| IUPAC name
Poly({2-methoxy-5-[2-(methylamino)ethyl]-1,3-phenylene}methylene)
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| Identifiers | |
| RTECS number |
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| UN number | 2811 |
| Properties | |
| (C11H15NO)n | |
| Molar mass | Variable |
| 50 mg/mL[1] | |
| Hazards | |
| GHS labelling: | |
| H301, H311, H331 | |
| P233, P261, P280, P301, P302, P304, P310, P312, P330, P340, P352, P403 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ^ a b "Compound48/80". Sigma-Aldrich.
- ^ A. M. Rothschild (1970). "Mechanisms of histamine release by compound 48/80". Br J Pharmacol. 38 (1): 253–262. doi:10.1111/j.1476-5381.1970.tb10354.x. PMC 1702640. PMID 4189829.
- ^ Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David (2012). "The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons". PLOS ONE. 7 (12): e52104. Bibcode:2012PLoSO...752104S. doi:10.1371/journal.pone.0052104. PMC 3525567. PMID 23272218.
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