Cristescu is a Romanian surname. Notable people with it include:
- Constantin Cristescu, Romanian General
- Daniel Cristescu, Romanian football defender
- Eugen Cristescu, Romanian secret police head
- Gheorghe Cristescu, Romanian socialist
- Marian Cristescu, Romanian football midfielder
- Melania Cristescu, Romanian–Canadian biologist and ecologist
- Silvian Cristescu, Romanian former professional footballer
- Vintilǎ Cristescu, Romanian long-distance runner