Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).
| Names | |
|---|---|
| IUPAC name
1-ethenylpyrrolidin-2-one
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Other names
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| Identifiers | |
| Abbreviations | PVPP |
| ChemSpider |
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| ECHA InfoCard | 100.110.608 |
| E number | E1202 (additional chemicals) |
CompTox Dashboard (EPA)
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| Pharmacology | |
| A07BC03 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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The cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets.[1] PVPP is a highly cross-linked version of PVP, making it insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets.
PVPP can be used as a drug, taken as a tablet or suspension to absorb compounds (so-called endotoxins) that cause diarrhea. (Cf. bone char, charcoal.)
It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced.[2] One such commercial product is called Polyclar. PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.[3]
PVPP has E number code E1202 and is used as a stabiliser.
See also
editReferences
edit- ^ "Povidones, Copovidones, and Crospovidones for Pharmaceutical Products". BASF Pharma. Retrieved 2022-06-11.
- ^ Microsoft Word - G0294.doc[dead link]
- ^ "A Novel Stabilization of Beer with Polyclar Brewbrite. Mustafa Rehmanji, Chandra Gopal, and Andrew Mola, MBAA TQ vol. 39, no. 1, 2002, pp. 24–28" (PDF). Archived from the original (PDF) on 2015-09-06. Retrieved 2017-05-19.