Déborah Bourc'his is a French researcher in Epigenetics. She is currently a team leader at the Curie Institute (Paris). Her research has been awarded the prize Liliane-Bettencourt for life sciences.
Education and academic appointments
editIn 1996.,[1] she joins the laboratory of Evani Viegas-Pequignot to do a PhD in Genetics in at the Necker–Enfants Malades Hospital.[2] There, she identifies methylation mutations on DNMT3B.
In 2000,[1] she moves to the laboratory of Timothy Bestor at the Columbia University to start her postdoctoral studies.
In 2009, after being recruited at the french biomedical research institute Inserm, she is invited by Edith Heard to start her own research team at the Curie Institute (Paris).[3]
Research
editDuring her postdoctoral studies, she shows that germline cells require a specific stimulation to acquire DNA methylation, via the cofactor 3 DNMT3L.[4]
Déborah Bourc'his runs a research team studying epigenetic decisions and reproduction[3] in the department 'Genetics and Developmental biology' of the Curie Institute.[5] Her research focuses on understanding the regulation of epigenetic information within the peri-conception window, from Gametogenesis to early embryonic development.[6] She has published several key publications in the field.[7][8] Her work has been awarded several prestigious prizes.
Awards
editReferences
edit- ^ a b "Déborah Bourc'his : Pasionaria de l'épigénétique". Inserm - La science pour la santé (in French). Retrieved 2020-05-07.
- ^ Bourc'his, Déborah (2000-01-01). Identification du gene et de l'origine embryonnaire du defaut de methylation de l'aon des patienst icf (thesis thesis). Paris 7.
- ^ a b "Epigenetic Decisions and Reproduction". Centre de recherche de l'Institut Curie. Retrieved 2020-05-07.
- ^ Bourc'his, Déborah; Bestor, Timothy H. (September 2004). "Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L". Nature. 431 (7004): 96–99. doi:10.1038/nature02886. ISSN 1476-4687. PMID 15318244. S2CID 4422237.
- ^ "U934/UMR3215 - Genetics and Developmental Biology". Centre de recherche de l'Institut Curie. Retrieved 2020-05-07.
- ^ "Le mystérieux rôle de l'épigénétique". Le Monde.fr (in French). 2018-10-17. Retrieved 2020-05-07.
- ^ Greenberg, Maxim V. C.; Glaser, Juliane; Borsos, Máté; Marjou, Fatima El; Walter, Marius; Teissandier, Aurélie; Bourc'his, Déborah (January 2017). "Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth". Nature Genetics. 49 (1): 110–118. doi:10.1038/ng.3718. ISSN 1546-1718. PMID 27841881. S2CID 4164945.
- ^ Barau, Joan; Teissandier, Aurélie; Zamudio, Natasha; Roy, Stéphanie; Nalesso, Valérie; Hérault, Yann; Guillou, Florian; Bourc’his, Déborah (2016-11-18). "The DNA methyltransferase DNMT3C protects male germ cells from transposon activity". Science. 354 (6314): 909–912. doi:10.1126/science.aah5143. ISSN 0036-8075. PMID 27856912. S2CID 30907442.
- ^ "Les lauréats 2017 des prix scientifiques de la Fondation Bettencourt Schueller". Fondation Bettencourt Schueller (in French). 2017-11-10. Retrieved 2020-05-07.
- ^ FSER, Cercle. "Cercle FSER". Cercle FSER (in French). Retrieved 2020-05-07.