Diazepam binding inhibitor

Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.

DBI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FJ9, 2CB8
Identifiers
Aliases	DBI, ACBD1, ACBP, CCK-RP, EP, Diazepam binding inhibitor, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein), diazepam binding inhibitor, acyl-CoA binding protein
External IDs	OMIM: 125950; MGI: 94865; HomoloGene: 39086; GeneCards: DBI; OMA:DBI - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.2 Start 119,366,924 bp End 119,372,550 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E2.3 Start 120,041,010 bp End 120,048,808 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vulva mucosa of transverse colon gingival epithelium sperm skin of thigh oral cavity mucosa of pharynx human penis skin of hip ventricular zone Top expressed in optic nerve brown adipose tissue white adipose tissue right kidney subcutaneous adipose tissue tunica adventitia of aorta lactiferous gland medial ganglionic eminence ventricular zone Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function benzodiazepine receptor binding lipid binding long-chain fatty acyl-CoA binding fatty-acyl-CoA binding protein dimerization activity Cellular component Golgi apparatus perinuclear endoplasmic reticulum extracellular exosome endoplasmic reticulum endoplasmic reticulum lumen Biological process protein palmitoylation phosphatidylcholine acyl-chain remodeling acyl-CoA metabolic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1622 13167 Ensembl ENSG00000155368 ENSMUSG00000026385 UniProt P07108 P31786 RefSeq (mRNA) NM_001079862 NM_001079863 NM_001178017 NM_001178041 NM_001178042 NM_001178043 NM_001282633 NM_001282634 NM_001282635 NM_001282636 NM_020548 NM_001352432 NM_001037999 NM_007830 RefSeq (protein) NP_001073331 NP_001073332 NP_001171488 NP_001171512 NP_001171513 NP_001171514 NP_001269562 NP_001269563 NP_001269564 NP_001269565 NP_065438 NP_001339361 NP_001033088 NP_031856 Location (UCSC) Chr 2: 119.37 – 119.37 Mb Chr 1: 120.04 – 120.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.

See also

• Diazepam

Further reading

• Papadopoulos V, Brown AS (1995). "Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis". J. Steroid Biochem. Mol. Biol. 53 (1–6): 103–110. doi:10.1016/0960-0760(95)00027-W. PMID 7626442. S2CID 41277281.
• Costa E, Auta J, Guidotti A, et al. (1994). "The pharmacology of neurosteroidogenesis". J. Steroid Biochem. Mol. Biol. 49 (4–6): 385–389. doi:10.1016/0960-0760(94)90284-4. PMID 8043504. S2CID 33492066.
• Mandrup S, Hummel R, Ravn S, et al. (1993). "Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family". J. Mol. Biol. 228 (3): 1011–1022. doi:10.1016/0022-2836(92)90888-Q. PMID 1469708.
• Webb NR, Rose TM, Malik N, et al. (1987). "Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand". DNA. 6 (1): 71–79. doi:10.1089/dna.1987.6.71. PMID 2881742.
• Gray PW, Glaister D, Seeburg PH, et al. (1986). "Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor". Proc. Natl. Acad. Sci. U.S.A. 83 (19): 7547–7551. Bibcode:1986PNAS...83.7547G. doi:10.1073/pnas.83.19.7547. PMC 386756. PMID 3020548.
• DeBernardi MA, Crowe RR, Mocchetti I, et al. (1988). "Chromosomal localization of the human diazepam binding inhibitor gene". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6561–6565. Bibcode:1988PNAS...85.6561D. doi:10.1073/pnas.85.17.6561. PMC 282013. PMID 3413112.
• Marquardt H, Todaro GJ, Shoyab M (1986). "Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor". J. Biol. Chem. 261 (21): 9727–9731. doi:10.1016/S0021-9258(18)67575-1. PMID 3525533.
• Swinnen JV, Esquenet M, Heyns W, et al. (1995). "Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP". Mol. Cell. Endocrinol. 104 (2): 153–162. doi:10.1016/0303-7207(94)90118-X. PMID 7527352. S2CID 29195251.
• Kolmer M, Rovio A, Alho H (1995). "The characterization of two diazepam binding inhibitor (DBI) transcripts in humans". Biochem. J. 306 (Pt 2): 327–330. doi:10.1042/bj3060327. PMC 1136524. PMID 7534063.
• Gersuk VH, Rose TM, Todaro GJ (1995). "Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor". Genomics. 25 (2): 469–476. doi:10.1016/0888-7543(95)80047-P. PMID 7789980.
• Alho H, Kolmer M, Harjuntausta T, Helén P (1995). "Increased expression of diazepam binding inhibitor in human brain tumors". Cell Growth Differ. 6 (3): 309–314. PMID 7794798.
• Alho H, Vaalasti A, Podkletnova I, Rechardt L (1994). "Expression of diazepam-binding inhibitor peptide in human skin: an immunohistochemical and ultrastructural study". J. Invest. Dermatol. 101 (6): 800–803. doi:10.1111/1523-1747.ep12371698. PMID 8245508.
• Cavallaro S, Pani L, Guidotti A, Costa E (1993). "ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action". Life Sci. 53 (14): 1137–1147. doi:10.1016/0024-3205(93)90550-M. PMID 8396705.
• Swinnen JV, Esquenet M, Rosseels J, et al. (1996). "A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP". DNA Cell Biol. 15 (3): 197–208. doi:10.1089/dna.1996.15.197. PMID 8634149.
• Krøll JB, Nøhr J, Gregersen N, et al. (1996). "Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum". Gene. 173 (2): 239–240. doi:10.1016/0378-1119(96)00214-4. PMID 8964506.
• Kolmer M, Pelto-Huikko M, Parvinen M, et al. (1997). "The transcriptional and translational control of diazepam binding inhibitor expression in rat male germ-line cells". DNA Cell Biol. 16 (1): 59–72. doi:10.1089/dna.1997.16.59. PMID 9022045.
• Ferrarese C, Cogliati T, Tortorella R, et al. (1998). "Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients". Epilepsy Res. 29 (2): 129–134. doi:10.1016/S0920-1211(97)00074-0. PMID 9477145. S2CID 2832298.