Dehydrogenase/reductase (SDR family) X-linked also known as DHRSX is an enzyme which in humans is encoded by the pseudoautosomal DHRSX gene.[4] DHRSX is a member of the short-chain dehydrogenase family of oxidoreductase enzymes.[5]

DHRSX
Identifiers
AliasesDHRSX, CXorf11, DHRS5X, DHRS5Y, DHRSXY, DHRSY, SDR46C1, SDR7C6, dehydrogenase/reductase (SDR family) X-linked, dehydrogenase/reductase X-linked
External IDsMGI: 2181510; HomoloGene: 78041; GeneCards: DHRSX; OMA:DHRSX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145177

NM_001033326

RefSeq (protein)

NP_660160

n/a

Location (UCSC)Chr X: 2.22 – 2.5 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

DHRSX is required for two steps in the biosynthesis of dolichol: i) the NAD+-dependent conversion of polyprenol to its aldehyde analogue, polyprenal; ii) the NADPH-dependent reduction of dolichal to dolichol.[6] Dolichol is a long polyisoprenoid lipid required as the carrier of mono- and oligosaccharides in the processes of N-glycosylation, C-/O-mannosylation and the formation of glycosylphosphatidylinositol (GPI) anchors.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169084Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, et al. (December 2001). "Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution". Genome Research. 11 (12): 2095–2100. doi:10.1101/gr.197001. PMC 311231. PMID 11731500.
  5. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  6. ^ Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, et al. (July 2024). "A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis". Cell. 187 (14): 3585–3601.e22. doi:10.1016/j.cell.2024.04.041. PMC 11250103. PMID 38821050.

Further reading

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