DMP1

Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.

DMP1
Identifiers
Aliases	DMP1, ARHP, ARHR, DMP-1, dentin matrix acidic phosphoprotein 1
External IDs	OMIM: 600980; MGI: 94910; HomoloGene: 68396; GeneCards: DMP1; OMA:DMP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q22.1 Start 87,650,280 bp End 87,664,361 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 E5|5 50.61 cM Start 104,350,479 bp End 104,361,968 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber tibia testicle trabecular bone tendon of biceps brachii sperm mucosa of paranasal sinus lateral nuclear group of thalamus upper respiratory tract sensory nervous system Top expressed in body of femur fossa molar cochlea calvaria lumbar subsegment of spinal cord ankle facial motor nucleus condyle otolith organ More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding integrin binding extracellular matrix binding Cellular component cytoplasm extracellular region nucleus endoplasmic reticulum lumen extracellular matrix Biological process biomineral tissue development extracellular matrix organization ossification positive regulation of cell-substrate adhesion regulation of enamel mineralization post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1758 13406 Ensembl ENSG00000152592 ENSMUSG00000029307 UniProt Q13316 O55188 RefSeq (mRNA) NM_001079911 NM_004407 NM_016779 NM_001359013 RefSeq (protein) NP_001073380 NP_004398 NP_058059 NP_001345942 Location (UCSC) Chr 4: 87.65 – 87.66 Mb Chr 5: 104.35 – 104.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional Arg-Gly-Asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

References

Cell Cycle-Dependent Nuclear Localization of DMP1

J.O. MANCERA1, T. JHALA2, S. WANG2, C. QIN2, R. D'SOUZA2, and Y. LU2, 1School of Dentistry, Meharry Medical College, Nashville, TN, 2Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX

Further reading

• George A, Sabsay B, Simonian PA, Veis A (1993). "Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization". J. Biol. Chem. 268 (17): 12624–30. doi:10.1016/S0021-9258(18)31434-0. PMID 8509401.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Srinivasan R, Chen B, Gorski JP, George A (2000). "Recombinant expression and characterization of dentin matrix protein 1". Connect. Tissue Res. 40 (4): 251–8. doi:10.3109/03008209909000703. PMID 10757113.
• Kulkarni GV, Chen B, Malone JP, et al. (2000). "Promotion of selective cell attachment by the RGD sequence in dentine matrix protein 1". Arch. Oral Biol. 45 (6): 475–84. doi:10.1016/S0003-9969(00)00010-8. PMID 10775676.
• Jain A, Karadag A, Fohr B, et al. (2002). "Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack". J. Biol. Chem. 277 (16): 13700–8. doi:10.1074/jbc.M110757200. PMID 11825898.
• Papagerakis P, Berdal A, Mesbah M, et al. (2002). "Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth". Bone. 30 (2): 377–85. doi:10.1016/S8756-3282(01)00683-4. PMID 11856645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Narayanan K, Ramachandran A, Hao J, et al. (2003). "Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store". J. Biol. Chem. 278 (19): 17500–8. doi:10.1074/jbc.M212700200. PMID 12615915.
• Chaplet M, De Leval L, Waltregny D, et al. (2004). "Dentin matrix protein 1 is expressed in human lung cancer". J. Bone Miner. Res. 18 (8): 1506–12. doi:10.1359/jbmr.2003.18.8.1506. PMID 12929940. S2CID 24870810.
• Steiglitz BM, Ayala M, Narayanan K, et al. (2004). "Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1". J. Biol. Chem. 279 (2): 980–6. doi:10.1074/jbc.M310179200. PMID 14578349.
• Toyosawa S, Tomita Y, Kishino M, et al. (2004). "Expression of dentin matrix protein 1 in tumors causing oncogenic osteomalacia". Mod. Pathol. 17 (5): 573–8. doi:10.1038/modpathol.3800084. PMID 15001995.
• Chen S, Inozentseva-Clayton N, Dong J, et al. (2005). "Binding of two nuclear factors to a novel silencer element in human dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression". J. Cell. Biochem. 92 (2): 332–49. doi:10.1002/jcb.20051. PMID 15108359. S2CID 31421133.
• Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. S2CID 17978869.
• Yang W, Lu Y, Kalajzic I, et al. (2005). "Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo". J. Biol. Chem. 280 (21): 20680–90. doi:10.1074/jbc.M500104200. PMID 15728181.
• Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs)". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904.
• Ling Y, Rios HF, Myers ER, et al. (2006). "DMP1 Depletion Decreases Bone Mineralization In Vivo: An FTIR Imaging Analysis". J. Bone Miner. Res. 20 (12): 2169–77. doi:10.1359/JBMR.050815. PMC 1456072. PMID 16294270.
• Karadag A, Fedarko NS, Fisher LW (2006). "Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44". Cancer Res. 65 (24): 11545–52. doi:10.1158/0008-5472.CAN-05-2861. PMC 1350722. PMID 16357164.
• Qin C, Huang B, Wygant JN, et al. (2006). "A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment". J. Biol. Chem. 281 (12): 8034–40. doi:10.1074/jbc.M512964200. PMID 16421105.