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2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine

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2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine (DOEF; also known as dimethoxyfluoroethylamphetamine) is a lesser-known psychedelic drug and member of the DOx class.[1][2] DOEF was first synthesized by Alexander Shulgin. In his book PiHKAL, the dosage range is listed as 2–3.5 mg, and the duration is listed as 12–16 hours.[3] Very little data exists about the pharmacological properties, metabolism, and toxicity of DOEF.

2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine
Names
Preferred IUPAC name
1-[4-(2-Fluoroethyl)-2,5-dimethoxyphenyl]propan-2-amine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C13H20FNO2/c1-9(15)6-11-8-12(16-2)10(4-5-14)7-13(11)17-3/h7-9H,4-6,15H2,1-3H3 checkY
    Key: QLENKWFQUHHBKZ-UHFFFAOYSA-N checkY
  • InChI=1/C13H20FNO2/c1-9(15)6-11-8-12(16-2)10(4-5-14)7-13(11)17-3/h7-9H,4-6,15H2,1-3H3
    Key: QLENKWFQUHHBKZ-UHFFFAOYAO
  • C1(=CC(=C(C=C1CC(C)N)OC)CCF)OC
  • COc1cc(CC(C)N)c(cc1CCF)OC
Properties
C13H20FNO2
Molar mass 241.306 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

See also

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References

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  1. ^ Gerdes, John M.; Mathis, Chester A.; Shulgin, Alexander T. (1988). "Synthesis of 1-[2′,5′-dimethoxy-4′-(β-fluoroethyl)phenyl]-2-aminopropane:studies related to 18F-labeled serotonin receptor ligands". Tetrahedron Letters. 29 (50): 6537–6539. doi:10.1016/S0040-4039(00)82391-6.
  2. ^ Trachsel, Daniel (2012). "Fluorine in psychedelic phenethylamines". Drug Testing and Analysis. 4 (7–8): 577–590. doi:10.1002/dta.413. PMID 22374819.
  3. ^ DOEF Entry in PiHKAL


 

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