DTK is an initialism that may refer to
- Developer Transition Kit, Apple's first ARM-based Macintosh computer for developers
- Dell OpenManage Deployment Toolkit
- Democratic Society Congress (Demokratik Toplum Kongresi), a pro-Kurdish NGO in Turkey
- Deutsche Bank Contingent Capital Trust III, listed as DTK on the New York Stock Exchange
- Diamond Trust Bank Group, traded as DTK on the Nairobi Securities Exchange
- Dunia Tanpa Koma, a TV series in Indonesia
- Duttapukur railway station (station code DTK), West Bengal, India
- DTK Computer, a defunct Taiwanese computer hardware company
- ISO 639:dtk, the Tomo Kan dialect of Western Plains Dogon