David Axelrod may refer to:
- David Axelrod (musician) (1931–2017), American composer, arranger and producer
- David Axelrod (political consultant) (born 1955), senior advisor to former U.S. President Barack Obama
- David Jason Axelrod Ha'ivri (born 1967), Israeli settler and political activist
- David Axelrod (physician) (1935–1994), medical doctor and New York State Commissioner of Health in the 1980s and 1990s