David Poole may refer to:
- David Poole (artist), portrait painter, see Andrew Huxley
- David Poole (dancer) (1925–1991), South African ballet dancer
- David Poole (footballer) (born 1984), English footballer
- David Poole (judge) (1938–2006), English High Court judge
- David Poole (researcher), artificial intelligence and machine learning researcher at University of British Columbia
- David C. Poole (born 1959), British-American physiologist