David Wolfe may refer to:
- David Wolfe (Jesuit) (died 1578), Irish papal legate
- David Wolfe (actor) (1915–1994)
- David A. Wolfe (born 1951), psychologist and author
- David Wolfe (raw food advocate) (born 1970), product spokesman and promoter of pseudoscientific theories
- David Wolfe (mathematician), co-author of Mathematical Go Endgames
- David W. Wolfe (born 1942), member of the New Jersey General Assembly
- David Møller Wolfe (born 2002), Norwegian footballer