Derk is a Dutch masculine given name. Notable people with the name include:
- Derk Bodde (1909-2003), American Sinologist
- Derk Boerrigter (born 1986), Dutch footballer
- Derk Cheetwood (born 1973), American actor
- Derk Droze (born 1972), American soccer player
- Derk Rijkens (born 1975), Dutch cricketer
- Derk Gerard Willem Spitzen (1896-1957), Dutch politician
- Derk Jan Eppink (born 1958), Dutch journalist
- Jacob Derk Carel van Heeckeren (1730-1795), Baron of Ruurlo