The τ and γ subunits are part of the DNA polymerase III holoenzyme of prokaryotes. The protein family is characterized by the well-conserved first N-terminal domain, approx. 365 amino acids. The eukaryotic equivalent to the DNA clamp loader is replication factor C, with the subunits RFC1, RFC2, RFC3, RFC4, and RFC5.
| DNA polymerase III tau subunit V interacting with alpha | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DNA_pol_III_sug/sutau | ||||||||
| Pfam | PF12170 | ||||||||
| InterPro | IPR012763 | ||||||||
| |||||||||
The domain is also found in plants as gene STICHEL (STI), with similarity to cyanobacterial sequences.[1] However, STI in plants is nuclear-localized and does not participate in genome duplication. It seems to instead regulate branching.[2]
References
edit- ^ Khan H, Parks N, Kozera C, Curtis BA, Parsons BJ, Bowman S, Archibald JM (August 2007). "Plastid genome sequence of the cryptophyte alga Rhodomonas salina CCMP1319: lateral transfer of putative DNA replication machinery and a test of chromist plastid phylogeny". Molecular Biology and Evolution. 24 (8): 1832–1842. doi:10.1093/molbev/msm101. PMID 17522086.
- ^ Ilgenfritz H, Bouyer D, Schnittger A, Mathur J, Kirik V, Schwab B, et al. (February 2003). "The Arabidopsis STICHEL gene is a regulator of trichome branch number and encodes a novel protein". Plant Physiology. 131 (2): 643–655. doi:10.1104/pp.014209. PMC 166840. PMID 12586888. S2CID 31931499.
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