Donald Moore may refer to:
- Don A. Moore (academic) (born 1970), American academic
- Don A. Moore (politician) (1928–2012), American judge, lawyer, and politician in Illinois
- Don Moore (musician) (born 1937), American jazz bassist
- Don Moore (politician) (1928–2017), American politician, member of the Tennessee House of Representative and Tennessee Senate
- Donnie Moore (1954–1989), American baseball pitcher
- Donald Willard Moore, Black Canadian civil rights activist
- Matt Moore (politician) (Donald Matthew Moore, born 1982), American political strategist