Donald Bryant may refer to:
- Donald "Isa" Hamm Bryant (1943–2007), American author, historian and activist
- Don Bryant (songwriter) (born 1942), American singer and songwriter
- Don Bryant (baseball) (1941–2015), catcher and coach in Major League Baseball
- Donald A. Bryant, American bioscientist and author
- Donald L. Bryant Jr. (born 1942), American businessman, art collector, vineyard owner and philanthropist