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Anne Rosenberg

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Anne Louise Rosenberg is an American surgical oncologist retired from practice in Cherry Hill, New Jersey.[1]

Anne Rosenberg
Born
Philadelphia, Pennsylvania
Alma materGoucher College (B.A.)
Thomas Jefferson University (M.D.)
Years active1981-2015
TitleOncologist

Career

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Rosenberg's career in medicine began in 1981, after graduating from Goucher College in Towson, Maryland and then attending medical school at Thomas Jefferson University, graduating with honors. She then completed surgical training at Thomas Jefferson University Hospital. She is board certified in Surgery by the American Board of Surgery.

Rosenberg is a clinical professor in surgery at Jefferson Medical College and was named Top Doctor by Philadelphia Magazine,[2] SJ Magazine,[3] and South Jersey Magazine[4] along with being featured in “A Day in the Life of the American Woman”.[5] Rosenberg has been published in numerous publications and scholarly journals including South Jersey Senior Magazine,[6] Journal of Ultrasound in Medicine,[7] The American Journal of Surgery,[8] International Seminars in Surgical Oncology, and Korean Nuclear Medicine Journal.[9]

Research

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Detection of breast cancer

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In the early 1980s, Rosenberg's early clinical research efforts were focused on validating the use of mammographic location of non-palpable breast lesions. Previously, there was no directed biopsy method for these abnormalities. These studies allowed histologic and radiographic findings to be correlated, and this laid the foundation for the development of the BIRADS classification for mammographic findings.[10][11][12]

Rosenberg, along with ultrasonographers, developed techniques for pre- and intraoperative ultrasound lesion localization with post excision evaluation of the tumor bed for confirmation of excision. These techniques were nearly 100% accurate with adequate lesion removal.[13] This work added ultrasound localization to the biopsy and lumpectomy procedures.[14]

Surgical treatment of breast cancer

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Based on the use of radiographic localization and acceptance of breast conservation therapy for breast cancer, Gordon Schwartz and Rosenberg described the management of the early-stage breast cancers, focusing on breast conservation. They also reported on the experience with lumpectomy, level 1 axillary node dissection followed by breast radiation (breast conservation) for the treatment of operable breast cancer (stage 1 and 2 disease). This work validated the effectiveness of breast conservation as an equivalent to mastectomy with regard to distant disease and local control and substantiated the need for radiation therapy and complete excision of the primary and established the acceptance of breast conservation therapy for breast cancer.[15][16]

Elderly women with breast cancer were reviewed and, although it was standard of care to perform mastectomy, Rosenberg's work, along with others at Jefferson University Hospital, confirmed that elderly women could be effectively treated with breast conservation and should be offered all surgical options, as the new standard of care.[17][18]

Introduction of neo-adjuvant chemotherapy also changes the standard of care for a more advanced stage, but localized breast cancers as 80% of women had a response to chemotherapy. The studies helped establish the length of neo-adjuvant chemotherapy needed and the increase in survival and disease-free survival when compared to women who did not receive neo-adjuvant chemotherapy. Disease-free survival improved three to four-fold and neo-adjuvant became the standard of care for a patient with larger tumors and nodal disease but no distant metastases.

In collaboration with Carl Mansfield, she reported on ten-year experience with interstitial implants in the breast to deliver the boost dose. This work changed the delivery of breast radiation by showing the complications from excessive boost radiation and also the reduced tumor recurrence when radiation was used. Interstitial implants were effective as method to deliver boost[19] and offered an abbreviated time frame to do so.[20]

In 1995, What to do if you get breast cancer was co-authored by Rosenberg with Marion Betancourt and Lydia Komarnicky, which promoted a new approach to disseminating information about diagnosis and management to patients.[21]

As a member of a cooperative group to validate the use of sentinel node biopsy for staging breast cancer, Dr. Rosenberg contributed to the study which changed the surgical management of the axilla for staging and treatment of breast cancer.[22][23][24][25]

In 2006, Rosenberg reported on and discussed the management of women with a history of breast augmentation who developed breast cancer. The conclusions were that treatment was to be individualized based upon the breast size and tumor location but both breast conservation and mastectomy were associated with similar survival, disease-free interval, and local recurrence. Breast conservation was a viable option to be offered to these women.[26][27]

Rosenberg popularized the use of brachytherapy devices (SAVI, mammosite) for local breast radiation for favorable breast cancers and she taught other surgeons the technique.[28]

Molecular studies

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Beginning in the mid-1990s, Rosenberg began to collect blood and surgical specimens of normal breast tissue, benign tumors, and malignant tumors. Evaluation of this tissue led to several observations that were important in understanding the biological behavior of malignancies. Croce and Rosenberg reported there was a loss of heterozygosity at 11q22-q23 in breast tumors.[29]

Collaborations with Croce were focused on microRNA expression and allowed the patterns of expression to be identified for target genes for tumors and by profiling the expression. These reproducible patterns of microRNA expression allowed for target tumor gene profiling, including male breast cancer.[30][31][32]

In collaboration with Hallguir Rui, they were the first to isolate a prolactin receptor-associated tyrosine kinase, and to identify this molecule as Janus kinase-2. These human tissue lines in a prolactin deficient mouse model allowed the definition of signal transduction by cytokine receptors and hormones with a primary goal of understanding the role of downstream JAK-STAT pathways and their aberrations in breast cancer. Together, they also demonstrated that the loss of Stat5 in estrogen-receptor-positive breast cancer is associated with increased risk of antiestrogen resistance and laid the groundwork for the patented matrix assembly technology for generation of high-density tumor tissue arrays for high-through-put molecular profiling.[33][34][35]

Personal life

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Rosenberg also has a working horse farm on 50 acres (20 ha) in Mount Laurel, New Jersey.[36][37] and is involved in women's initiatives and breast cancer awareness, clinical research trials, as well as numerous scientific presentations. She is also active with the Alliance of Therapy Dogs, American Kennel club Club and Crisis Response Canines.[38]

She was recognized with a Community Service Award by the 101 Women Plus organization.[39]

References

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  1. ^ "Pet Tales: Therapy dogs lend a healing paw, heart in Squirrel Hill, Oakland" Pittsburgh Post-Gazette. Retrieved 2019-07-01.
  2. ^ "BREASTS, BEWARE: What the Mammogram Mayhem Means to You" Philadelphia Magazine. Retrieved 2019-07-01.
  3. ^ "Top Docs 2014" SJ Magazine. Retrieved 2019-07-01.
  4. ^ "Best Physicians 2013" South Jersey Magazine. Retrieved 2019-07-01.
  5. ^ "A Day in the Life of the American Woman: Construction and Mediation of the “American Woman” in Photographic Essays" TransAtlantica. Retrieved 2019-07-01.
  6. ^ "The Facts About Breast Cancer" South Jersey Senior Magazine. Retrieved 2019-07-01.
  7. ^ "Intraoperative sonographic localization of breast masses: success with specimen sonography and surgical bed sonography to confirm excision." Journal of Ultrasound in Medicine. Retrieved 2019-07-01.
  8. ^ "Prognostic indicators following ipsilateral tumor recurrence in patients treated with breast-conserving therapy." The American Journal of Surgery. Retrieved 2019-07-01.
  9. ^ "Anne L. Rosenberg" Semantic Scholar. Retrieved 2019-07-01.
  10. ^ Schwartz, G. F.; Feig, S. A.; Rosenberg, A. L.; Patchefsky, A. S.; Shaber, G. S. (1984). "Localization and Significance of Clinically Occult Breast Lesions: Experience with 469 Needle-Guided Biopsies". Early Detection of Breast Cancer. Recent Results in Cancer Research. Vol. 90. pp. 125–132. doi:10.1007/978-3-642-82031-1_18. ISBN 978-3-642-82033-5. PMID 6701369.
  11. ^ Schwartz, G. F.; Feig, S. A.; Rosenberg, A. L.; Patchefsky, A. S.; Schwartz, A. B. (1984). "Staging and treatment of clinically occult breast cancer". Cancer. 53 (6): 1379–1384. doi:10.1002/1097-0142(19840315)53:6<1379::aid-cncr2820530627>3.0.co;2-r. PMID 6692326.
  12. ^ Rosenberg, A. L.; Schwartz, G. F.; Feig, S. A.; Patchefsky, A. S. (1987). "Clinically occult breast lesions: Localization and significance". Radiology. 162 (1 Pt 1): 167–170. doi:10.1148/radiology.162.1.3024209. PMID 3024209.
  13. ^ Vilaro, M. M.; Kurtz, A. B.; Needleman, L.; Fleischer, A. C.; Mitchell, D. G.; Rosenberg, A.; Miller, C.; Rifkin, M. D.; Pennell, R.; Baltarowich, O.; Goldberg, B. B. (1989). "Hand-held and automated sonomammography. Clinical role relative to X-ray mammography". Journal of Ultrasound in Medicine. 8 (2): 95–100. doi:10.7863/jum.1989.8.2.95. PMID 2651697.
  14. ^ Feld, R. I.; Rosenberg, A. L.; Nazarian, L. N.; Needleman, L.; Lev-Toaff, A. S.; Segal, S. R.; Johnson, P. T.; Parker, L.; O'Reilly, T. (2001). "Intraoperative sonographic localization of breast masses: Success with specimen sonography and surgical bed sonography to confirm excision". Journal of Ultrasound in Medicine. 20 (9): 959–966. doi:10.7863/jum.2001.20.9.959. PMID 11549156.
  15. ^ Schwartz, Gordon F.; Rosenberg, Anne L.; Danoff, Barbara F.; Mansfield, Carl M.; Feig, Stephen A. (1984). "Lumpectomy and Level I Axillary Dissection Prior to irradiation for "Operable" Breast Cancer". Annals of Surgery. 200 (4): 554–560. doi:10.1097/00000658-198410000-00016. PMC 1250529. PMID 6435551.
  16. ^ Schwartz, G. F.; d'Ugo, D. M.; Rosenberg, A. L. (1986). "Extent of axillary dissection preceding irradiation for carcinoma of the breast". Archives of Surgery. 121 (12): 1395–1398. doi:10.1001/archsurg.1986.01400120041006. PMID 3024603.
  17. ^ Geriatrics 48: Supplement 1: 9-13, 1993 June.
  18. ^ "Role of immediate reconstruction for elderly breast cancer patients" Jefferson Digital Commons. 2007.
  19. ^ Mansfield, C. M.; Komarnicky, L. T.; Schwartz, G. F.; Rosenberg, A. L.; Krishnan, L.; Jewell, W. R.; Rosato, F. E.; Moses, M. L.; Haghbin, M.; Taylor, J. (1995). "Ten-year results in 1070 patients with stages I and II breast cancer treated by conservative surgery and radiation therapy". Cancer. 75 (9): 2328–2336. doi:10.1002/1097-0142(19950501)75:9<2328::aid-cncr2820750923>3.0.co;2-l. PMID 7712444.
  20. ^ Mansfield, C. M.; Komarnicky, L. T.; Schwartz, G. F.; Rosenberg, A. L.; Krishnan, L.; Jewell, W. R.; Rosato, F. E.; Moses, M. L.; Barbot, D.; Cohn, H. E. (1994). "Perioperative implantation of iridium-192 as the boost technique for stage I and II breast cancer: Results of a 10-year study of 655 patients". Radiology. 192 (1): 33–36. doi:10.1148/radiology.192.1.8208960. PMID 8208960.
  21. ^ Komarnicky, Lydia; Rosenberg, Anne; Betancourt, Marian (1995). What to do if You Get Breast Cancer. Little, Brown. ISBN 0316092894.
  22. ^ McGuire, K.; Rosenberg, A. L.; Showalter, S.; Brill, K. L.; Copit, S. (2007). "Timing of sentinel lymph node biopsy and reconstruction for patients undergoing mastectomy". Annals of Plastic Surgery. 59 (4): 359–363. doi:10.1097/SAP.0b013e3180326fb9. PMID 17901723.
  23. ^ Blumencranz, Peter; Whitworth, Pat W.; Deck, Kenneth; Rosenberg, Anne; Reintgen, Douglas; Beitsch, Peter; Chagpar, Anees; Julian, Thomas; Saha, Sukamal; Mamounas, Eleftherios; Giuliano, Armando; Simmons, Rache (2007). "Sentinel node staging for breast cancer: intraoperative molecular pathology overcomes conventional histologic sampling errors". The American Journal of Surgery. 194 (4): 426–432. doi:10.1016/j.amjsurg.2007.07.008. PMID 17826050.
  24. ^ Julian, Thomas B.; Blumencranz, Peter; Deck, Kenneth; Whitworth, Pat; Berry, Donald A.; Berry, Scott M.; Rosenberg, Anne; Chagpar, Anees B.; Reintgen, Douglas; Beitsch, Peter; Simmons, Rache; Saha, Sukamal; Mamounas, Eleftherios P.; Giuliano, Armando (2008). "Novel intraoperative molecular test for sentinel lymph node metastases in patients with early-stage breast cancer". Journal of Clinical Oncology. 26 (20): 3338–3345. doi:10.1200/JCO.2007.14.0665. ISSN 1527-7755. PMID 18612150.
  25. ^ Blumencranz, Peter; Whitworth, Pat W.; Deck, Kenneth; Rosenberg, Anne; Reintgen, Douglas; Beitsch, Peter; Chagpar, Anees; Julian, Thomas; Saha, Sukamal; Mamounas, Eleftherios; Giuliano, Armando; Simmons, Rache (2007). "Scientific Impact Recognition Award. Sentinel node staging for breast cancer: intraoperative molecular pathology overcomes conventional histologic sampling errors". American Journal of Surgery. 194 (4): 426–432. doi:10.1016/j.amjsurg.2007.07.008. ISSN 1879-1883. PMID 17826050.
  26. ^ Tuli, Richard; Flynn, Ryan A.; Brill, Kristin L.; Sabol, Jennifer L.; Usuki, Kenneth Y.; Rosenberg, Anne L. (2006). "Diagnosis, treatment, and management of breast cancer in previously augmented women". The Breast Journal. 12 (4): 343–348. doi:10.1111/j.1075-122X.2006.00273.x. ISSN 1075-122X. PMID 16848844.
  27. ^ "Breast Conservation for the Treatment of Breast Cancer in the Previously Augmented Patient". 32nd Annual Symposium of the American Society of Breast Disease, San Diego, California, April 10–12, 2008.
  28. ^ Attai, Deanna J.; Strasser, Jon (2013). "Accelerated Partial Breast Irradiation". Oncology Issues. 28 (2): 36–39. doi:10.1080/10463356.2013.11883837.
  29. ^ "Detection and Cloning of a Common Region of Loss of Heterozygosity at Chromosome Ip in Breast Cancer" Cancer Research Journal. Retrieved 2019-08-06.
  30. ^ Iorio, M. V.; Ferracin, M.; Liu, C. G.; Veronese, A.; Spizzo, R.; Sabbioni, S.; Magri, E.; Pedriali, M.; Fabbri, M.; Campiglio, M.; Ménard, S.; Palazzo, J. P.; Rosenberg, A.; Musiani, P.; Volinia, S.; Nenci, I.; Calin, G. A.; Querzoli, P.; Negrini, M.; Croce, C. M. (2005). "MicroRNA gene expression deregulation in human breast cancer". Cancer Research. 65 (16): 7065–7070. doi:10.1158/0008-5472.CAN-05-1783. PMID 16103053.
  31. ^ Baffa, Raffaele; Fassan, Matteo; Volinia, Stefano; O'Hara, Brian; Liu, Chang-Gong; Palazzo, Juan P.; Gardiman, Marina; Rugge, Massimo; Gomella, Leonard G.; Croce, Carlo M.; Rosenberg, Anne (2009). "MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets". The Journal of Pathology. 219 (2): 214–221. doi:10.1002/path.2586. PMID 19593777.
  32. ^ Fassan, Matteo; Baffa, Raffaele; Palazzo, Juan P.; Lloyd, Joshua; Crosariol, Marco; Liu, Chang-Gong; Volinia, Stefano; Alder, Hannes; Rugge, Massimo; Croce, Carlo M.; Rosenberg, Anne (2009). "MicroRNA expression profiling of male breast cancer". Breast Cancer Research. 11 (4): R58. doi:10.1186/bcr2348. PMC 2750120. PMID 19664288.
  33. ^ "Prolactin Inhibits BCL6 Expression in Breast Cancer through a Stat5a-Dependent Mechanism" Cancer Research Journal. Retrieved 2019-08-04.
  34. ^ Peck, Amy R.; Witkiewicz, Agnieszka K.; Liu, Chengbao; Stringer, Ginger A.; Klimowicz, Alexander C.; Pequignot, Edward; Freydin, Boris; Tran, Thai H.; Yang, Ning; Rosenberg, Anne L.; Hooke, Jeffrey A.; Kovatich, Albert J.; Nevalainen, Marja T.; Shriver, Craig D.; Hyslop, Terry (2011). "Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure". Journal of Clinical Oncology. 29 (18): 2448–2458. doi:10.1200/JCO.2010.30.3552. PMC 3675698. PMID 21576635.
  35. ^ Peck, Amy R.; Witkiewicz, Agnieszka K.; Liu, Chengbao; Klimowicz, Alexander C.; Stringer, Ginger A.; Pequignot, Edward; Freydin, Boris; Yang, Ning; Ertel, Adam; Tran, Thai H.; Girondo, Melanie A.; Rosenberg, Anne L.; Hooke, Jeffrey A.; Kovatich, Albert J.; Shriver, Craig D. (2012). "Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes". Breast Cancer Research. 14 (5): R130. doi:10.1186/bcr3328. PMC 4053108. PMID 23036105.
  36. ^ "Room at the Inn (House)" SJMag. Retrieved 2019-07-01.
  37. ^ "Partnership brings Lourdes formal pet therapy services" Burlington County Times. Retrieved 2019-07-01.
  38. ^ "Meet the newest breed of therapy dog" Philly Voice. Retrieved 2019-07-01.
  39. ^ "In Your County" Press of Atlantic City. Retrieved 2019-07-01.
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