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He Jiankui

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In this Chinese name, the family name is Hè (贺).

He Jiankui ([xɤ̂ tɕjɛ̂nkʰwěɪ]; 贺建奎; born 1984) is a Chinese biophysicist. He was named as the inaugural director of the Institute of Genetic Medicine at Wuchang Technical College, a private undergraduate college in Wuhan, in September 2023.[2] Before January 2019, He served as associate professor at the Department of Biology of the Southern University of Science and Technology (SUSTech) in Shenzhen, Guangdong, China.[3][4][5] Earning a PhD from Rice University in Texas on protein evolution, including that of CRISPR, He learned gene-editing techniques (CRISPR/Cas9) as a postdoctoral researcher at Stanford University in California.[6]

He Jiankui
贺建奎
He in 2018
Born1984 (age 39–40)
Xinhua County, Hunan, China
Alma materUniversity of Science and Technology of China (BS)
Rice University (PhD)
Known forHe Jiankui affair
Scientific career
FieldsBiophysics
InstitutionsSouthern University of Science and Technology
ThesisSpontaneous Emergence of Hierarchy in Biological Systems (2011)
Doctoral advisorMichael W. Deem
Other academic advisorsStephen Quake[1]
Chinese name
Simplified Chinese贺建奎
Traditional Chinese賀建奎
Transcriptions
Standard Mandarin
Hanyu PinyinHè Jiànkuí
IPA[xɤ̂ tɕjɛ̂nkʰwěɪ]

In November 2018, He announced that he had created the first human genetically edited babies,[7][8] twin girls who were born in mid-October 2018 and known by their pseudonyms, Lulu and Nana.[9][10][6][1] The announcement was initially praised in the press as a major scientific advancement.[11] But following scrutiny on how the experiment was executed, He received widespread condemnation.[6][12][13] His research activities were suspended by the Chinese authorities on 29 November 2018,[14] and he was fired by SUSTech on 21 January 2019.[15] On 30 December 2019, a Chinese court found He Jiankui guilty of illegal practice of medicine and sentenced him to three years in prison and a fine of 3 million yuan.[16] He was released from prison in April 2022.[17]

He was listed as one of Time's 100 most influential people of 2019, in the section "Pioneers".[18] At the same time he was variously referred to as a "rogue scientist",[19] "China's Dr. Frankenstein",[20] and a "mad genius".[21]

Early life and education

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He was born in Xinhua County, Loudi City, Hunan, in 1984.[10]

He Jiankui attended the University of Science and Technology of China for undergraduate studies from 2002 to 2006, and graduated with a major in modern physics in 2006.[10] He entered Rice University in 2007 and received a Doctor of Philosophy degree in biophysics under the supervision of Michael W. Deem in 2010.[10][22][23]

After receiving his doctorate, Michael Deem arranged for He to work on CRISPR/Cas9 gene-editing technique as a postdoc fellow with Stephen Quake at Stanford University.[3][1][24]

Career

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In 2011, He received the Chinese Government Award for Outstanding Self-financed Students Abroad while still in the United States.[25] Responding to an ad, He returned to China in 2012 under the city of Shenzhen's Peacock Plan[25] and opened a lab at the Southern University of Science and Technology (SUSTech).[24] As part of the program, he was given 1 million yuan (about US$145,000 in 2012) in angel funding, which he used to start biotech and investment companies.[26][27] He founded Direct Genomics in 2012 in Shenzhen, to develop single-molecule sequencing devices based on patents invented by Quake that had formerly been licensed by Helicos Biosciences. Direct Genomics received 40 million yuan (about US$5,790,000 in 2012) in subsidies from Shenzhen, and raised hundreds of millions yuan more in private investment, but He sold his stake in 2019.[26][28] He also founded Vienomics Biotech, which offers genome sequencing services for people with cancer.[27] In 2017, He was included in the Chinese government's Thousand Talents Plan.[29][30] He Jiankui's achievements were widely revered in Chinese media, including China Central Television and the People's Daily[25] which covered his research and described him as "the founding father of third-generation genome editing" during a program celebrating the 19th National Congress of the Chinese Communist Party.[31]

In August 2018, He met with Chinese-American doctor John Zhang to discuss plans to launch a company focused on "genetic medical tourism." The business was to target elite customers, operating out of China or Thailand.[32] The business plans were shelved with He's detainment in November 2018.[3]

He took an unpaid leave from SUSTech starting in February 2018, and began conducting the genome-editing clinical experiment.[33][34][35] On 26 November 2018, he announced the birth of gene-edited human babies, Lulu and Nana.[34] Three days later, on 29 November 2018, Chinese authorities suspended all of his research activities, saying that his work was "extremely abominable in nature" and a violation of Chinese law.[14] In December 2018, following public outcry regarding his work, He appeared to have gone missing. SUSTech denied the widespread rumors that he had been detained.[36] On 30 December 2019, the Shenzhen Nanshan District People's Court sentenced He Jiankui to three years in prison and a fine of three million yuan (about US$434,000 in 2019).[37][38][39] He Jiankui was released in April 2022 after serving the term.[40][41]

Research

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In 2010, at Rice University, He Jiankui and Michael W. Deem published a paper describing some details of the CRISPR protein; this paper was part of the early work on the CRISPR/Cas9 system, before it had been adopted as a gene editing tool.[24]

In 2017, He gave a presentation at Cold Spring Harbor Laboratory describing work he did at Southern University of Science and Technology (SUSTech), in which he used CRISPR/Cas9 on mice, monkeys, and around 300 human embryos.[42]

In January 2019, scientists in China reported the creation of five identical cloned gene-edited monkeys, using the same cloning technique that was used with Zhong Zhong and Hua Hua – the first ever cloned monkeys - and Dolly the sheep, and the same gene-editing CRISPR/Cas9 technique allegedly used by He in creating the first ever gene-modified human babies Lulu and Nana. The monkey clones were made in order to study several medical diseases.[43][44]

Human gene-editing experiment

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On 25 November 2018, He Jiankui first announced on YouTube that his team successfully created the world's first genome-edited babies, Lulu and Nana.[45] Formally presenting the story at the Second International Summit on Human Genome Editing at the University of Hong Kong (HKU) three days later, he said that the twins were born from genetically modified embryos that were made resistant to M-tropic strains of HIV.[46] His team recruited 8 couples consisting each of HIV-positive father and HIV-negative mother through Beijing-based HIV volunteer group called Baihualin China League. During in vitro fertilization, the sperms were cleansed of HIV. Using CRISPR/Cas9 gene-editing, they introduced a natural mutation CCR5-Δ32 in gene called CCR5, which would confer resistance to M-tropic HIV infection. The People's Daily announced the result as "a historical breakthrough in the application of gene editing technology for disease prevention".[11]

The experiment had recruited couples who wanted to have children; in order to participate, the man had to be HIV-positive and the woman uninfected.[34] At the time, it was not disclosed whether the clinical experiment had received appropriate ethical review from an institutional review board before it started, and it was unclear if the participants had given truly informed consent.[9][34]

He Jiankui said that he edited the genomes of the embryos using CRISPR/Cas9, specifically targeting a gene, CCR5, that codes for a protein that HIV-1 uses to enter cells.[47][48] He was trying to create a specific mutation in the gene, (CCR5 Δ32), that few people naturally have and that possibly confers innate resistance to HIV-1,[47] as seen in the case of the Berlin Patient.[49] He said that the girls still carried functional copies of CCR5 along with disabled CCR5 given mosaicism inherent in the present state of the art in germ-line editing.[9] There are forms of HIV which use a different receptor instead of CCR5, and the work that He did could not protect resulting children from those forms of HIV.[47]

He Jiankui said he used a preimplantation genetic diagnosis process on the embryos that were edited, where 3 to 5 single cells were removed and the editing was checked. He said that parents were offered the choice of using edited or unedited embryos.[34]

The twin girls were born by mid-October 2018, according to emails from He to an adviser.[50] According to He, they appeared to be healthy in all respects.[9] When they were born, it was unclear if there might be long-term effects from the gene-editing; He was asked about his plans to monitor the children, and pay for their care should any problems arise, and how their confidentiality and that of their parents could remain protected.[9] The names of the children used in reports, "Lulu" and "Nana", along with the names of their parents, "Mark" and "Grace", are pseudonyms.[51] In February 2019, He's claims were reported to have been confirmed by Chinese investigators, according to NPR News.[52]

He Jiankui also said at the Hong Kong meeting that a second mother in his clinical experiment was in the early stages of pregnancy.[9] Although there are no official reports, the baby was expected around August 2019,[53] and the birth was confirmed from the court verdict on 30 December which mentioned that there were three genetically edited babies.[54] The baby was later revealed in 2022 as Amy.[55]

In February 2022, Chinese scientists called for building a special facility to care for and study the three children born with genetically edited genomes or 'CRISPR Babies'. They assert that errors could have occurred in the gene editing process. The scientists believe the children's genomes should be regularly sequenced and tested for 'abnormalities'. The proposal has received pushback from the international medical community citing invasion of the children's privacy and future abuses of power.[56][57]

Gene therapy for rare diseases

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On 10 November 2022, He announced that he was setting up a new laboratory in Beijing for research on gene therapy for rare genetic diseases, saying on Twitter: "Today, I moved in my new office in Beijing. This is the first day for Jiankui He Lab."[58] On 24 November, he wrote: "Gene therapy in Western countries often costs millions of dollars, which makes many families fall into poverty due to illness. With the support of social philanthropists, we will overcome three to five genetic diseases within two to three years to benefit families with rare diseases."[59][60] His first plan is to make a gene therapy for Duchenne muscular dystrophy that causes gradual muscle degeneration particularly in boys.[61] He also said on a microblogging site, Weibo, that he had applied for government funding for a DNA synthesiser project, commenting: "[I will] continue the scientific research and serve the country... The biggest use of the DNA synthesiser I plan to make is for information storage. A fingernail-sized piece of synthetic DNA can store the contents of books from the entire national library."[62]

Human gene-editing controversy

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Main article: He Jiankui affair
 
He Jiankui speaking at the Second International Summit on Human Genome Editing

Revelation

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He Jiankui's human gene-editing clinical experiment was conducted without public discussion in the scientific community.[12][7] It was first made public on 25 November 2018 when Antonio Regalado published a story about the work in MIT Technology Review,[42] based on documents that had been posted earlier that month on the Chinese clinical trials registry. He Jiankui refused to comment on whether the pregnancies were aborted or carried on.[42] It was only after the story was posted that the experiment was revealed in a promotional video on YouTube by He Jiankui and the next day in the Associated Press report.[34] He Jiankui had engaged a public relations firm as well.[24]

Reaction

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He Jiankui's conduct was widely condemned.[51][63][64] On 26 November, 122 Chinese scientists issued a joint statement that He's works were unethical, crazy, insane, and "a huge blow to the global reputation and development of Chinese science".[11] Other Chinese scientists and institutions harshly criticized He; an article in Nature stated that concerns about He's conduct were "particularly acute in China, where scientists are sensitive to the country's reputation as the Wild West of biomedical research".[64] An eminent bioethicist, Ren-zong Qiu, speaking at the Second International Summit on Human Genome Editing, commented on He's research as "a practice with the least degree of ethical justifiability and acceptability".[11] Geneticist Eric Topol stated, "This is far too premature ... We're dealing with the operating instructions of a human being. It's a big deal."[65] Nobel prize-winning biologist David Baltimore considered the work "irresponsible".[47] Developmental biologist Kathy Niakan of the Francis Crick Institute said, "If true...this would be a highly irresponsible, unethical and dangerous use of genome editing technology."[51] Medical ethicist Julian Savulescu of the University of Oxford noted, "If true, this experiment is monstrous."[51] Bioethicist Henry T. Greely of Stanford Law School declared, "I unequivocally condemn the experiment,"[66] and later, "He Jiankui’s experiment was, amazingly, even worse than I first thought."[67] Nobel prize-winning biochemist Jennifer Doudna, of the University of California, Berkeley, a pioneer of the CRISPR/Cas9 technology, condemned the research.[64][68] The National Institutes of Health (NIH) of United States announced a statement on 28 November 2018 signed by its Director Francis S. Collins, condemning He and his team for intentionally flouting international ethical norms by doing such irresponsible work, and criticizing that He's "project was largely carried out in secret, the medical necessity for inactivation of CCR5 in these infants is utterly unconvincing, the informed consent process appears highly questionable, and the possibility of damaging off-target effects has not been satisfactorily explored". NIH claims no support for the use of gene-editing technologies in human embryos.[69] The Chinese Academy of Medical Sciences published an announcement in the journal Lancet, stating that they "are opposed to any clinical operation of human embryo genome editing for reproductive purposes in violation of laws, regulations, and ethical norms in the absence of full scientific evaluation", and condemning He for violating relevant ethical regulations and guidelines that have been clearly documented by the Chinese government. They emphasized that the "genome editing of germ cells or early embryos is still in the stage of basic research, ... scientific research institutions and researchers should not undertake clinical operations of genome editing of human germ cells for reproductive purposes, nor should they fund such research", and they will "develop and issue further operational technical and ethical guidelines as soon as possible to guide and standardise relevant research and applications according to the highest scientific and ethical standards."[70] In April 2019, genetics experts from the Chinese Academy of Science (CAS) noted, “[We] believe there is no sound scientific reason to perform this type of gene editing on the human germline, and that the behavior of He [Jiankui] and his team represents a gross violation of both the Chinese regulations and the consensus reached by the international science community. We strongly condemn their actions as extremely irresponsible, both scientifically and ethically.”[13]

Others were less critical of He's experiment. George Church, a geneticist at Harvard University, defended some aspects of the experiment and said gene editing for HIV resistance was "justifiable" since HIV is "a major and growing public health threat", but questioned the decision of this project to allow one of the embryos to be used in a pregnancy attempt, since the use of that embryo suggests that the researchers’ "main emphasis was on testing editing rather than avoiding this disease".[66][71] Arthur Caplan, bioethicist at the New York University School of Medicine, said that engineering human genes is inevitable and, although there are concerns of creating "designer babies", medical researchers are more interested in using the technology to prevent and treat diseases, much like the type of experiments performed by He.[72] Carl Zimmer compared the reaction to He's human gene editing experiment to the initial reactions and subsequent debate over mitochondrial replacement therapy (MRT), and the eventual regulatory approval of MRT in the United Kingdom.[73]

Investigation

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The Southern University of Science and Technology stated that He Jiankui had been on unpaid leave since February 2018, and his research was conducted outside of their campus; the university and his department said they were unaware of the research project and said it was inviting international experts to form an independent committee to investigate the incident, and would release the results to the public.[35] Local authorities and the Chinese government also opened investigations.[14]

As of news reported on 28 December 2018, He was sequestered in a university apartment and under guard.[74][75] According to news reported on 7 January 2019, he could face severe consequences.[76][77] William Hurlbut, Stanford University neuroscientist and bioethicist, reported that he was in contact with He who was staying in a university apartment in Shenzhen “by mutual agreement” and was free to leave; often visiting the gym and taking walks with his wife.[78] Nonetheless, He may have been under some form of surveillance.[74][75][79]

On 25 February 2019, some suggested the Chinese government may have helped fund the CRISPR babies experiment, at least in part.[80][81][82] Later reports showed that the fund for He's project was raised by himself to evade regulation, and no Chinese government funds were involved.[15][83]

Preliminary authoritative report

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An investigating task force set up by the Guangdong Provincial Health Commission released a preliminary report on January 21, 2019, stated that He Jiankui had defied government bans and conducted the research in the pursuit of personal fame and gain. The report confirmed that He had recruited eight couples to participate in his experiment, resulting in two pregnancies, one of which gave birth to the gene-edited twin girls in November 2018. The babies are now under medical supervision. The report further said He had made forged ethical review papers in order to enlist volunteers for the procedure, and had raised his own funds deliberately evading oversight, and organized a team that included some overseas members to carry out the illegal project. Officials from the investigation said that He, as well as other relevant personnel and organizations, will receive punishment per relevant laws and regulations, and those who are suspected of committing crimes will be charged.[15][83]

Aftermath

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The SUSTech announced a statement on its website on 21 January 2019 that He Jiankui had been fired.[15]

On 30 December 2019, the Shenzhen City Nanshan District People's Court sentenced He Jiankui to three years in prison and fined him 3 million RMB (about US$434,000).[37][38] His collaborators received less penalty – Zhang Renli of the Guangdong Academy of Medical Sciences and Guangdong General Hospital, a two-year prison sentence and a 1-million RMB (about US$145,000) fine, and Qin Jinzhou of the Southern University of Science and Technology, an 18-month prison sentence and a 500,000 RMB (about US$72,000) fine.[84] The three were found guilty of having "forged ethical review documents and misled doctors into unknowingly implanting gene-edited embryos into two women."[85]

In May 2019, lawyers in China reported, in light of the purported creation by He Jiankui of the first gene-edited humans, the drafting of regulations that anyone manipulating the human genome by gene-editing techniques would be held responsible for any related adverse consequences.[86] In December 2019, MIT Technology Review reported an overview of the controversy to date, including excerpts of the unpublished research manuscript.[87][88]

In February 2019, scientists reported that the gene modification made in Lulu and Nana likely also confers cognitive benefits.[89] While health journalist Julia Belluz has speculated in Vox that this may have been a motivation for He Jiankui to work on modifying this gene,[82]) Antonio Regalado of MIT Technology Review found no evidence that He Jiankui had interest in this area.[89]

In 2019, the World Health Organization (WHO) has launched a global registry to track research on human genome editing, after a call to halt all work on genome editing.[90][91][92]

After the incident

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On 21 February 2023, Hong Kong newspaper Ming Pao reported that He Jiankui said his application for a Hong Kong entry permit through the Top Talent Pass Scheme had been approved.[93] Late that night, the Government of Hong Kong made a public announcement, suggesting that after inspecting the relevant applications, the Immigration Department suspected that He Jiankui had obtained a Hong Kong entry permit by making false statements. The Director of Immigration had declared He Jiankui's entry permit invalid, and a criminal investigation would be conducted.[94][95][96][97][98]

On 8 September 2023, Wuchang Technical College (武昌理工学院), a private undergraduate college in Wuhan, Hubei, established the Institute of Genetic Medicine, with He Jiankui serving as the inaugural director.[2]

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  • He Jiankui's life and his CRISPR experiment were presented in the documentary Make People Better, released in 2022.[58][99] The film described, "A Chinese scientist disappears after developing the first designer babies, shocking the world and the entire scientific community, but an investigation shows he may not have been alone in his experiment to create "better" human beings."[100] Directed by Cody Sheehy, the expert panel included Antonio Regalado and Benjamin Hurlbut of the Arizona State University.[101] The documentary originated from a Rhumbline Media project on genetic engineering titled Code of the Wild: The Nature of Us started in 2018 by Sheehy and Samira Kiani, a biotechnologist at Arizona State University.[102][103]
  • His account is depicted in The CRISPR Generation: The Story of the World’s First Gene-Edited Babies, a 2019 book by Kiran Musunuru, a cardiologist at the University of Pennsylvania.[104][105]
  • His story is narrated in the 2020 book The Mutant Project: Inside the Global Race to Genetically Modify Humans, written by Eben Kirksey, an anthropologist at the University of Oxford.[106][107]
  • A documentary book CRISPR People: The Science and Ethics of Editing Humans, written by Henry Greely, was published in 2021.[108][109]

See also

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References

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  1. ^ a b c Bulluck, Pam (14 April 2019). "Gene-Edited Babies: What a Chinese Scientist Told an American Mentor". The New York Times. Retrieved 14 April 2019.
  2. ^ a b "武昌理工学院成立基因药物研究所". hb.people.com.cn. Retrieved 20 September 2024.
  3. ^ a b c Cohen, Jon (1 August 2019). "The untold story of the 'circle of trust' behind the world's first gene-edited babies". Science. doi:10.1126/science.aay9400. Archived from the original on 13 October 2021. Retrieved 1 August 2019.
  4. ^ "Jiankui He（Nonpaid Leave）- Department of Biology". bio.sustc.edu.cn. Archived from the original on 2 January 2019. Retrieved 6 December 2018.
  5. ^ Rana, Preetika (10 May 2019). "How a Chinese Scientist Broke the Rules to Create the First Gene-Edited Babies - Dr. He Jiankui, seeking glory for his nation and justice for HIV-positive parents, kept his experiment secret, ignored peers' warnings and faked a test (Paywall)". The Wall Street Journal. Archived from the original on 5 April 2023. Retrieved 11 May 2019.
  6. ^ a b c Begley, Sharon; Joseph, Andrew (17 December 2018). "The CRISPR shocker: How genome-editing scientist He Jiankui rose from obscurity to stun the world". Stat News. Archived from the original on 17 December 2018. Retrieved 17 December 2018.
  7. ^ a b The Editorial Board (28 January 2019). "Should Scientists Toy With the Secret to Life? - The gene-editing technology Crispr has the power to remake life as we know it. Questions about how to use it concern everyone". The New York Times. Archived from the original on 29 January 2019. Retrieved 29 January 2019.
  8. ^ "The scientist who created CRISPR babies is on Time's most-influential list—but not in a good way". MIT Technology Review. 18 April 2019. Archived from the original on 18 April 2019. Retrieved 18 April 2019.
  9. ^ a b c d e f Begley, Sharon (28 November 2018). "Amid uproar, Chinese scientist defends creating gene-edited babies". STAT News. Archived from the original on 31 January 2019. Retrieved 29 November 2018.
  10. ^ a b c d 复盘贺建奎的人生轨迹：是谁给了他勇气 (in Chinese). sina.com.cn. 27 November 2018. Archived from the original on 28 November 2018. Retrieved 28 November 2018.
  11. ^ a b c d Li, Jing-ru; Walker, Simon; Nie, Jing-bao; Zhang, Xin-qing (2019). "Experiments that led to the first gene-edited babies: the ethical failings and the urgent need for better governance". Journal of Zhejiang University Science B. 20 (1): 32–38. doi:10.1631/jzus.B1800624. PMC 6331330. PMID 30614228.
  12. ^ a b Kolata, Gina; Belluck, Pam (5 December 2018). "Why Are Scientists So Upset About the First Crispr Babies? - Only because a rogue researcher defied myriad scientific and ethical norms and guidelines. We break it down". The New York Times. Archived from the original on 30 January 2019. Retrieved 5 December 2018.
  13. ^ a b Dvorsky, George (30 April 2019). "Substandard, Superficial, and Absurd: Experts Slam the Science Behind the CRISPR Baby Experiment". Gizmodo. Archived from the original on 30 April 2019. Retrieved 30 April 2019.
  14. ^ a b c Jiang, Steven; Regan, Helen; Berlinger, Joshua (29 November 2018). "China suspends scientists who claim to have produced first gene-edited babies". CNN News. Archived from the original on 29 November 2018. Retrieved 30 November 2018.
  15. ^ a b c d Shepherd, Christian; Wong, Sue-Lin; Kelland, Kate (21 January 2019). "Chinese scientist who gene-edited babies fired by university". Reuters. Archived from the original on 22 January 2019. Retrieved 23 January 2019.
  16. ^ ""基因编辑婴儿"案贺建奎已释放，曾获刑三年". finance.sina.com.cn. 7 April 2022. Retrieved 20 September 2024.
  17. ^ "The creator of the CRISPR babies has been released from a Chinese prison". 4 April 2022. Archived from the original on 23 July 2022. Retrieved 7 April 2022.
  18. ^ Doudna, Jennifer (18 April 2019). "100 Most Influential People - He Jiankui". Time. Archived from the original on 17 March 2021. Retrieved 18 April 2019.
  19. ^ Cohen, Jon (2 August 2019). "Inside the circle of trust". Science. 365 (6452): 430–437. Bibcode:2019Sci...365..430C. doi:10.1126/science.365.6452.430. PMID 31371593.
  20. ^ Yan, Sophia (28 November 2018). "China's 'Dr Frankenstein' says second woman in early pregnancy with gene-edited babies". The Telegraph. Retrieved 10 January 2020.
  21. ^ Low, Zoe (27 November 2018). "China's gene editing Frankenstein had dreams of being Chinese Einstein". South China Morning Post. Archived from the original on 10 January 2020. Retrieved 10 January 2020.
  22. ^ "Spontaneous Emergence of Hierarchy in Biological Systems - ProQuest". www.proquest.com. Retrieved 20 September 2024.
  23. ^ "贺建奎 – 师资队伍". Southern University of Science and Technology. Archived from the original on 21 July 2018. Retrieved 20 September 2024.
  24. ^ a b c d Joseph, Andrew; Robbins, Rebecca; Begley, Sharon (27 November 2018). "An outsider claimed genome-editing history; the world snapped to attention". STAT News. Archived from the original on 27 February 2019. Retrieved 29 November 2018.
  25. ^ a b c Mecklin, John (13 January 2019). "Brave new world with Chinese characteristics". Bulletin of the Atomic Scientists. Archived from the original on 26 April 2023. Retrieved 26 April 2023.
  26. ^ a b Coleman, Zach (27 November 2018). "The businesses behind the doctor who manipulated baby DNA". Nikkei Asian Review. Archived from the original on 30 November 2018. Retrieved 30 November 2018.
  27. ^ a b He Jiankui, Laura; Zhang, Jane; Moon, Louise (29 November 2018). "Who are the investors supporting He Jiankui, the Chinese scientist behind the gene-edited babies?". South China Morning Post. Archived from the original on 30 November 2018. Retrieved 30 November 2018.
  28. ^ "Chinese 'baby editing' scientist retreats from flagship company". Nikkei Asian Review. Archived from the original on 7 September 2019. Retrieved 8 September 2019.
  29. ^ "The untold story of the 'circle of trust' behind the world's first gene-edited babies". www.science.org. Archived from the original on 5 April 2023. Retrieved 26 April 2023.
  30. ^ King, Mike (6 December 2018). "He Jiankui's Genetic Misadventure: Why Him? Why China?". Journal of Medical Ethics blog. Archived from the original on 26 April 2023. Retrieved 26 April 2023.
  31. ^ 【短片】賀建奎曾上央視「迎十九大」節目 被譽「第三代基因測序儀鼻祖」 (23:00) - 20181129 - 兩岸 (in Chinese (Hong Kong)). Ming Pao. Archived from the original on 7 December 2018. Retrieved 30 December 2019.
  32. ^ Regalado, Antonio. "Disgraced CRISPR scientist had plans to start a designer-baby business". MIT Technology Review. Archived from the original on 1 August 2019. Retrieved 2 August 2019.
  33. ^ Cyranoski, David; Ledford, Heidi (26 November 2018). "Genome-edited baby claim provokes international outcry". Nature. 563 (7733): 607–608. Bibcode:2018Natur.563..607C. doi:10.1038/d41586-018-07545-0. PMID 30482929. S2CID 53768039.
  34. ^ a b c d e f Marchione, Marilyn (26 November 2018). "Chinese researcher claims first gene-edited babies". AP NEWS. Archived from the original on 26 November 2018. Retrieved 30 November 2018.
  35. ^ a b 南科大：贺建奎2月已停薪留职 项目违背学术伦理. Sina. 26 November 2018. Archived from the original on 26 November 2018. Retrieved 28 November 2018.
  36. ^ "Whereabouts of Gene-Editing Doctor He Jiankui Unknown". Time. Archived from the original on 15 March 2019. Retrieved 4 December 2018.
  37. ^ a b Wee, Sui-Lee (30 December 2019). "Chinese Scientist Who Genetically Edited Babies Gets 3 Years in Prison - He Jiankui's work was also carried out on a third infant, according to China's state media, in a new disclosure that is likely to add to the global uproar over such experiments". The New York Times. Archived from the original on 30 December 2019. Retrieved 30 December 2019.
  38. ^ a b Yee, Isaac; Hollingsworth, Julia (30 December 2019). "Chinese gene-editing scientist jailed for 3 years". CNN News. Archived from the original on 30 December 2019. Retrieved 30 December 2019.
  39. ^ "Chinese scientist who produced genetically altered babies sentenced to 3 years in jail". www.science.org. Archived from the original on 26 April 2023. Retrieved 26 April 2023.
  40. ^ Regalado, Antonio (4 April 2022). "The creator of the CRISPR babies has been released from a Chinese prison". MIT Technology Review. Archived from the original on 23 July 2022. Retrieved 5 April 2022.
  41. ^ Cohen, Jon (21 March 2022). "As creator of 'CRISPR babies' nears release from prison, where does embryo editing stand?". Science. doi:10.1126/science.acx9233. Archived from the original on 9 January 2023. Retrieved 9 January 2023.
  42. ^ a b c Regalado, Antonio (25 November 2018). "Chinese scientists are creating CRISPR babies". MIT Technology Review. Archived from the original on 27 November 2018. Retrieved 30 November 2018.
  43. ^ Science China Press (23 January 2019). "Gene-edited disease monkeys cloned in China". EurekAlert!. Archived from the original on 24 January 2019. Retrieved 24 January 2019.
  44. ^ Mandelbaum, Ryan F. (23 January 2019). "China's Latest Cloned-Monkey Experiment Is an Ethical Mess". Gizmodo. Archived from the original on 24 January 2019. Retrieved 24 January 2019.
  45. ^ Dyer, Owen (2018). "Researcher who edited babies' genome retreats from view as criticism mounts". BMJ. 363: k5113. doi:10.1136/bmj.k5113. PMID 30504437. S2CID 54485094.
  46. ^ "Scientist defends 'gene-edited' babies". BBC. 28 November 2018. Archived from the original on 23 September 2019. Retrieved 6 January 2020.
  47. ^ a b c d Belluck, Pam (28 November 2018). "Chinese Scientist Who Says He Jiankui Edited Babies' Genes Defends His Work". The New York Times. Archived from the original on 29 November 2018. Retrieved 30 November 2018.
  48. ^ de Silva E, Stumpf MP (December 2004). "HIV and the CCR5-Delta32 resistance allele". FEMS Microbiology Letters. 241 (1): 1–12. doi:10.1016/j.femsle.2004.09.040. PMID 15556703.
  49. ^ ""Menschenversuche": Geburt genmanipulierter Babys verkündet". Stern (in German). 26 November 2018. Archived from the original on 29 November 2018. Retrieved 30 November 2018.
  50. ^ Belluck, Pam (14 April 2019). "Gene-Edited Babies: What a Chinese Scientist Told an American Mentor". The New York Times.
  51. ^ a b c d "China Orders Investigation After Scientist Claims First Gene-Edited Babies". The New York Times. Reuters. 26 November 2018. Archived from the original on 27 November 2018.
  52. ^ Schmitz, Rob (5 February 2019). "Gene-Editing Scientist's 'Actions Are A Product Of Modern China'". NPR News. Archived from the original on 5 February 2019. Retrieved 5 February 2019.
  53. ^ Cyranoski, David (2019). "The CRISPR-baby scandal: what's next for human gene-editing". Nature. 566 (7745): 440–442. Bibcode:2019Natur.566..440C. doi:10.1038/d41586-019-00673-1. PMID 30809070.
  54. ^ Huaxia (30 December 2019). "Three jailed in China's "gene-edited babies" trial - Xinhua | English.news.cn". www.xinhuanet.com. Archived from the original on 30 December 2019. Retrieved 9 January 2020.
  55. ^ Gutierrez C., Nicolas (29 June 2022). "What's next for the gene-edited children from CRISPR trial in China?". New Scientist. Archived from the original on 9 January 2023. Retrieved 9 January 2023.
  56. ^ Mallapaty, Smriti (25 February 2022). "How to protect the first 'CRISPR babies' prompts ethical debate". Nature. 603 (7900): 213–214. Bibcode:2022Natur.603..213M. doi:10.1038/d41586-022-00512-w. PMID 35217837. S2CID 247129684. Archived from the original on 6 March 2022. Retrieved 6 March 2022.
  57. ^ "Scientists Call for Special Facility to Care for Genetically Modified Children". Futurism. Archived from the original on 5 March 2022. Retrieved 6 March 2022.
  58. ^ a b Schaefer, G. Owen (20 December 2022). "Did He Jiankui 'Make People Better'? Documentary spurs a new look at the case of the first gene-edited babies". The Conversation. Archived from the original on 11 January 2023. Retrieved 11 January 2023.
  59. ^ Pandaily (28 November 2022). "Chinese Gene-Editing Scientist He Jiankui Sets Up Beijing Lab Following Prison Release". Pandaily. Archived from the original on 28 November 2022. Retrieved 9 January 2023.
  60. ^ Habershon, Alfie (28 November 2022). "Imprisoned Chinese Gene Scientist Sets Up New Lab - Pandaily". Asia Financial. Archived from the original on 9 January 2023. Retrieved 9 January 2023.
  61. ^ Mullin, Emily (1 December 2022). "The Crispr Baby Scientist Is Back. Here's What He's Doing Next". Wired. ISSN 1059-1028. Archived from the original on 8 January 2023. Retrieved 9 January 2023.
  62. ^ Xie, Echo (8 September 2022). "Chinese gene-edited babies scientist seeks funding for DNA synthesiser". South China Morning Post. Archived from the original on 9 January 2023. Retrieved 9 January 2023.
  63. ^ Begley, Sharon (26 November 2018). "Claim of CRISPR'd baby girls stuns genome editing summit". STAT News. Archived from the original on 27 November 2018.
  64. ^ a b c Cyranoski, David (27 November 2018). "How the genome-edited babies revelation will affect research". Nature. doi:10.1038/d41586-018-07559-8. S2CID 158314199. Archived from the original on 27 November 2018.
  65. ^ Topol, Eric (27 November 2018). "Editing Babies? We Need to Learn a Lot More First". The New York Times. Archived from the original on 27 November 2018.
  66. ^ a b Farr, Cristina (26 November 2018). "Experiments to gene-edit babies are 'criminally reckless,' says Stanford bio-ethicist". CNBC. Archived from the original on 27 November 2018.
  67. ^ Greely, Henry T. (15 April 2019). "He Jiankui, embryo editing, CCR5, the London patient, and jumping to conclusions". Stat News. Archived from the original on 15 April 2019. Retrieved 15 April 2019.
  68. ^ Leuty, Ron (27 November 2018). "Why 2 key gene-editing voices in Berkeley condemn Chinese scientist's designer babies 'stunt'". San Francisco Business Times. Retrieved 28 November 2018.
  69. ^ Collins, Francis S. (28 November 2018). "Statement on Claim of First Gene-Edited Babies by Chinese Researcher". www.nih.gov. Bethesda, Maryland 20892: National Institutes of Health（NIH）. Archived from the original on 4 December 2018. Retrieved 6 December 2018.{{cite web}}: CS1 maint: location (link)
  70. ^ Wang, Chen; Zhai, Xiaomei; Zhang, Xinqing; Li, Limin; Wang, Jianwei; Liu, De-pei (30 November 2018). "Gene-edited babies:Chinese Academy of Medical Sciences'response and action". Lancet. 393 (10166): 25–26. doi:10.1016/S0140-6736(18)33080-0. PMID 30522918.
  71. ^ Cohen, Jon (28 November 2018). "'I feel an obligation to be balanced.' Noted biologist comes to defense of gene editing babies". Science | AAAS. Archived from the original on 24 October 2021. Retrieved 8 September 2019.
  72. ^ Almendrala, Anna (27 November 2018). "World's First Gene-Edited Babies Could Set Genetic Science Backward, Experts Worry". Huffington Post. Archived from the original on 28 November 2018. Retrieved 30 November 2018.
  73. ^ Zimmer, Carl (1 December 2018). "Genetically Modified People Are Walking Among Us". The New York Times.
  74. ^ a b Chen, Elsi; Mozur, Paul (28 December 2018). "Chinese Scientist Who Claimed to Make Genetically Edited Babies Is Kept Under Guard". The New York Times. Archived from the original on 29 December 2018. Retrieved 29 December 2018.
  75. ^ a b Senthilingam, Meera (7 January 2019). "Chinese scientist was told not to create world's first gene-edited babies". CNN News. Archived from the original on 21 January 2019. Retrieved 7 January 2019.
  76. ^ Hess, Peter (8 January 2019). "Chinese Scientist Who Gene-Edited Babies Responds to Death Penalty Rumors". Inverse. Archived from the original on 10 January 2019. Retrieved 9 January 2019.
  77. ^ Dvorsky, George (7 January 2019). "Chinese Scientist Who Created CRISPR Babies Could Face the Death Penalty, Fellow Geneticist Warns". Gizmodo. Archived from the original on 7 January 2019. Retrieved 7 January 2019.
  78. ^ Begley, Sharon (9 January 2019). "'CRISPR babies' scientist: 'I'm actually doing quite well'". StatNews. Archived from the original on 15 January 2019. Retrieved 14 January 2019.
  79. ^ Ramzy, Austin; Wee, Sui-Lee (21 January 2019). "Scientist Who Edited Babies' Genes Is Likely to Face Charges in China". The New York Times. Archived from the original on 21 January 2019. Retrieved 21 January 2019.
  80. ^ Qiu, Jane (25 February 2019). "Chinese government funding may have been used for 'CRISPR babies' project, documents suggest". STAT News. Archived from the original on 2 March 2019. Retrieved 1 March 2019.
  81. ^ Chen, Angela (26 February 2019). "New documents suggest Chinese government helped fund the CRISPR babies experiment". The Verge. Retrieved 1 March 2019.
  82. ^ a b Belluz, Julia (4 March 2019). "CRISPR babies: the Chinese government may have known more than it let on - The latest developments in the gene-editing saga raise more questions than answers". Vox. Retrieved 4 March 2019.
  83. ^ a b "Guangdong releases preliminary investigation result of gene-edited babies". Xinhua News Agency. 21 January 2019. Archived from the original on 21 January 2019. Retrieved 23 January 2019.
  84. ^ Cyranoski, David (3 January 2020). "What CRISPR-baby prison sentences mean for research - Chinese court sends strong signal by punishing He Jiankui and two colleagues". Nature. 577 (7788): 154–155. doi:10.1038/d41586-020-00001-y. PMID 31911693.
  85. ^ Normile, Dennis (30 December 2019). "Chinese scientist who produced genetically altered babies sentenced to 3 years in jail". Science. doi:10.1126/science.aba7347. S2CID 213806642.
  86. ^ Cyranoski, David (20 May 2019). "China set to introduce gene-editing regulation following CRISPR-baby furore - The draft rules mean that anyone who manipulates human genes in adults or embryos is responsible for adverse outcomes". Nature. doi:10.1038/d41586-019-01580-1. PMID 32424191. S2CID 182604140. Archived from the original on 20 May 2019. Retrieved 20 May 2019.
  87. ^ Regalado, Antonio (3 December 2019). "China's CRISPR babies: Read exclusive excerpts from the unseen original research - He Jiankui's manuscript shows how he ignored ethical and scientific norms in creating the gene-edited twins Lulu and Nana". MIT Technology Review. Archived from the original on 4 December 2019. Retrieved 3 December 2019.
  88. ^ Musunuru, Kiran (3 December 2019). "Opinion: We need to know what happened to CRISPR twins Lulu and Nana - The unpublished research paper by He Jiankui about the creation of the babies shows proof of attempted gene editing gone awry". MIT Technology Review. Archived from the original on 9 December 2019. Retrieved 3 December 2019.
  89. ^ a b Regalado, Antonio (21 February 2019). "China's CRISPR twins might have had their brains inadvertently enhanced - New research suggests that a controversial gene-editing experiment to make children resistant to HIV may also have enhanced their ability to learn and form memories". MIT Technology Review. Archived from the original on 22 February 2019. Retrieved 21 February 2019.
  90. ^ "The World Health Organization Says No More Gene-Edited Babies". WIRED. 30 July 2019. Archived from the original on 8 November 2019. Retrieved 26 November 2019.
  91. ^ "WHO To Create Registry for Genetic Research". Voice of America. 29 August 2019. Archived from the original on 2 December 2019. Retrieved 26 November 2019.
  92. ^ "The WHO panel calls for registry of all human gene editing research". Reuters. 20 March 2019. Retrieved 26 November 2019.
  93. ^ "基因嬰案判囚 賀建奎高才通獲批 稱港「開放包容城市」 擬研遺傳病基因治療". 明報. 21 February 2023. Retrieved 21 February 2023.
  94. ^ "政府發言人回應傳媒查詢". 香港政府新聞公報 (in Chinese). Archived from the original on 5 June 2023. Retrieved 21 February 2023.
  95. ^ "Hong Kong revokes work visa given to scientist jailed for medical malpractice". South China Morning Post. 21 February 2023. Archived from the original on 3 October 2023. Retrieved 10 September 2023.
  96. ^ "Controversial doctor who gene-edited babies gets Hong Kong visa". The Straits Times. 21 February 2023. ISSN 0585-3923. Archived from the original on 28 July 2023. Retrieved 10 September 2023.
  97. ^ Hawkins, Amy; Davidson, Helen (22 February 2023). "Scientist convicted of editing babies' genes has Hong Kong visa revoked over 'false statement'". The Guardian. ISSN 0261-3077. Retrieved 10 September 2023.
  98. ^ Standard, The. "Jailed Chinese scientist who edited babies' genes granted Hong Kong talent scheme visa". The Standard. Archived from the original on 3 October 2023. Retrieved 10 September 2023.
  99. ^ Greely, Henry T. (1 December 2022). "CRISPR Babies and the Great Wall of Silence". GEN Biotechnology. 1 (6): 487–488. doi:10.1089/genbio.2022.29072.htg. ISSN 2768-1572. S2CID 254726827. Archived from the original on 26 December 2022. Retrieved 11 January 2023.
  100. ^ "Make People Better". Make People Better. Archived from the original on 11 January 2023. Retrieved 11 January 2023.
  101. ^ July, Beandrea (14 December 2022). "'Make People Better' Review: Clear Science, Confusing Storytelling". The New York Times. ISSN 0362-4331. Archived from the original on 11 January 2023. Retrieved 11 January 2023.
  102. ^ Price, Dianne (20 December 2018). "Experts wrestle with today's tough biotechnology questions at third Arizona Biosecurity Workshop". ASU News. Archived from the original on 11 January 2023. Retrieved 11 January 2023.
  103. ^ Molteni, Megan (13 December 2022). "'Make People Better': The CRISPR babies story you probably don't know, and how it was filmed in real-time". STAT. Archived from the original on 11 January 2023. Retrieved 11 January 2023.
  104. ^ Musunuru, Kiran (29 November 2019). The CRISPR Generation: The Story of the World's First Gene-Edited Babies. BookBaby. ISBN 978-1-5439-8637-2. Archived from the original on 5 April 2023. Retrieved 11 January 2023.
  105. ^ Gostimskaya, Irina (2022). "CRISPR-Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing". Biochemistry. Biokhimiia. 87 (8): 777–788. doi:10.1134/S0006297922080090. ISSN 1608-3040. PMC 9377665. PMID 36171658.
  106. ^ Eben, Kirksey (2021). The Mutant Project: Inside the Global Race to Genetically Modify Humans. St. Martin's Publishing Group. ISBN 978-1-2502-6535-7. Archived from the original on 5 April 2023. Retrieved 21 March 2023.
  107. ^ Kamal, Sarah (2022). "Review: Eben Kirksey, The Mutant Project: Inside the Global Race to Genetically Modify Humans. New York: St. Martin's Press, 2020". Logos Journal. Archived from the original on 11 January 2023. Retrieved 11 January 2023.
  108. ^ Greely, Henry T. (2021). CRISPR People: The Science and Ethics of Editing Humans. MIT Press. ISBN 978-0-262-54388-0. Archived from the original on 8 April 2023. Retrieved 11 January 2023.
  109. ^ Temple-Raston, Dina (21 May 2021). "Review | CRISPR gives us the power to short-circuit evolution. What now?". Washington Post. ISSN 0190-8286. Archived from the original on 21 May 2022. Retrieved 11 January 2023.
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