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Jason Sheltzer

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Jason Sheltzer is a cancer biologist at the Yale University School of Medicine.[1]

Education

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Sheltzer received a BA in molecular biology from Princeton University and a PhD in biology from the Massachusetts Institute of Technology.[2][3] At MIT, Sheltzer performed his PhD research with Angelika Amon on the consequences of aneuploidy.[4] Sheltzer then established his own research group as an independent fellow at Cold Spring Harbor Laboratory.[5][3] In 2021 Sheltzer was recruited to move his lab to Yale University.[1]

Career and research

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Sheltzer uses CRISPR/Cas9 technology to study aneuploidy and cancer genomics.[6][7] Through the use of chromosome engineering, he has constructed cancer cells with different degrees of aneuploidy, and he has found how aneuploidy affects tumor development and metastasis.[8][9][10] In 2019, he discovered a set of copy number alteration biomarkers that can be used to predict cancer patient outcomes.[5][11][12] His research has questioned whether anti-cancer drugs could be acting through alternate mechanisms.[13][14][15] He is a co-founder of Meliora Therapeutics.[16]

Sheltzer also studies gender disparities in biology research. He discovered that some faculty members, like Nobel Prize winners, tended to hire very few female students in their labs, which could contribute to the gender gap in STEM.[17][18][19]

Awards and honors

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References

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  1. ^ a b Smith, Cecelia. "Geneticist and Diversity Champion Jason Sheltzer Brings Award-Winning Research Lab to Yale Surgery". medicine.yale.edu. Retrieved 2021-12-26.
  2. ^ Austin, Jim (2014-07-08). "A Young Tag Team Detects a Major Pipeline Leak". Science | AAAS. Retrieved 2020-06-06.
  3. ^ a b "AACR-Bayer Innovation and Discovery Grants | American Association for Cancer Research". American Association for Cancer Research (AACR). Retrieved 2020-06-06.
  4. ^ "McKinley and Sheltzer to Receive 2016 Bernfield and Gilula Awards". ASCB. 2016-10-06. Retrieved 2020-06-06.
  5. ^ a b Ricks, Delthia (2018-12-25). "Researcher aims to take uncertainty out of cancer diagnosis". Newsday. Retrieved 2020-06-06.
  6. ^ "Fox 5 (New York): Modifying Cancer Cell Genomes [The Big Idea]". YouTube. 2018-09-20.
  7. ^ Kaiser, Jocelyn (2019-09-11). "Some cancer drugs miss their target. CRISPR could improve their aim". Science | AAAS. Retrieved 2020-06-20.
  8. ^ Seton-Rogers, Sarah (March 2017). "Fitness penalties of aneuploidy". Nature Reviews Cancer. 17 (3): 142–143. doi:10.1038/nrc.2017.9. ISSN 1474-1768. PMID 28184042. S2CID 41054562.
  9. ^ Seton-Rogers, Sarah (2020-03-31). "Weighing up effects of extra chromosomes". Nature Reviews Cancer. 20 (5): 259. doi:10.1038/s41568-020-0257-y. ISSN 1474-175X. PMID 32235903. S2CID 214718880.
  10. ^ Johnson, Carolyn Y. (2023-07-06). "Gene editing helped crack a 100-year-old mystery about cancer". Washington Post. ISSN 0190-8286. Retrieved 2023-07-16.
  11. ^ Thomas, Uduak Grace (2018-12-18). "Cancer Genetic Studies Explore Prognostic Value of Copy Number Alterations, Other Biomarkers". GenomeWeb. Retrieved 2020-06-06.
  12. ^ Dunaief, Daniel. "CSHL's Jason Sheltzer and Google's Joan Smith team up in cancer study | TBR News Media". Retrieved 2020-06-20.
  13. ^ Zimmer, Carl (2019-09-11). "Why Aren't Cancer Drugs Better? The Targets Might Be Wrong". The New York Times. ISSN 0362-4331. Retrieved 2020-06-06.
  14. ^ Belluz, Julia (2019-09-16). "Most cancer drugs fail in testing. This might be a big reason why". Vox. Retrieved 2020-06-06.
  15. ^ Preidt, Robert (2019-09-11). "Cancer Drugs Sometimes Work in Unexpected Ways: Study". U.S. News & World Report.
  16. ^ Gormley, Brian. "Biotech Meliora Therapeutics Gets $11 Million Seed Financing for Cancer Treatments". WSJ. Retrieved 2023-07-16.
  17. ^ McGregor, Jenna (2014-07-17). "Study: Top labs run by men tend to hire fewer women". The Washington Post.
  18. ^ Dockterman, Eliana (2014-07-09). "Study: Male Scientists Employ Fewer Women in Labs". Time. Retrieved 2020-06-06.
  19. ^ Hu, Jane C. (2014-06-30). "Male Professors Rarely Train Female Scientists". Slate Magazine. Retrieved 2020-06-06.
  20. ^ "Jason Sheltzer, 28". Forbes. Retrieved 2020-06-06.
  21. ^ "McKinley and Sheltzer to Receive 2016 Bernfield and Gilula Awards". ASCB. 2016-11-07. Retrieved 2020-09-17.
  22. ^ "President Donald J. Trump Announces Recipients of the Presidential Early Career Award for Scientists and Engineers". whitehouse.gov. Retrieved 2020-06-06 – via National Archives.
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