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Lev T. Perelman

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Lev T. Perelman is an American biological physicist and bioengineer at Harvard. He holds the Mary Tolan and Edward Grzelakowski Endowed Chair, is a professor of medicine at Harvard Medical School, and is the Director of the Center for Advanced Biomedical Imaging and Photonics at Beth Israel Deaconess Medical Center.[1] He is known for his work on biomedical light scattering spectroscopy and application of optics and spectroscopy to life sciences and developmental and cell biology.[2][3][4]

Lev T. Perelman
Scientific career
FieldsBiological physics, Bioengineering
InstitutionsHarvard University

Harvard Medical School

Beth Israel Deaconess Medical Center
Website

Background and education

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Perelman is the son of theoretical physicist Theodore L. Perelman, who solved the Conjugate convective heat transfer problem and made contributions in the development of a two-temperature model that describes electron and phonon temperature distributions in metals heated by ultrashort-pulsed lasers.[5]

Perelman completed his undergraduate degree in theoretical physics from Belarus University and doctoral degree in physics from Institute of Physics in Minsk in 1989. He joined MIT in 1992 as a postdoctoral fellow in biological physics.[6]

Career

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Perelman was appointed a principal scientist at MIT in 1995. He joined Harvard faculty in 2000 where he is currently a professor.[1]

Perelman was a member of the United States Department of Health and Human Services Joint Working Group charged with setting up funding priorities in oncologic imaging in the U.S.[7]

Research

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Perelman with Vadim Backman, an HST graduate student, introduced biomedical light scattering spectroscopy (LSS) in 1998.[8] This approach was later applied for detection of precancer in esophagus,[9][10] colon,[11][12] urinary bladder and oral cavity,[11] cervix,[13][14] pancreatic cysts,[15][16] and bile duct.[17] This technique was later extended to subcellular scales with development of confocal light absorption and scattering spectroscopic microscopy[18][19] for label-free subcellular functional imaging, sensing chromatin packing in live cells,[20] and demonstrating that exosomes promote tumorigenesis.[21]

Perelman's other contributions include demonstration of the world's first single-molecule detection with Surface-enhanced Raman Spectroscopy (SERS),[22] and explanation of the critical role of stress confinement in short pulse laser ablation and laser surgery.[23] He also developed with John Marshall the first non-hydrostatic model of the ocean known as the MIT General Circulation Model.[24][25]

References

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  1. ^ a b "Lev Perelman Harvard Profile". Harvard University. Archived from the original on December 7, 2022.
  2. ^ "Light-scattering tool peers into pancreas to find cancer". NSF - National Science Foundation. Retrieved April 3, 2023.
  3. ^ New tool for early detection of pancreatic cancer!, retrieved April 3, 2023
  4. ^ WINTERS, CATHERINE (June 16, 2017). "The Latest Cancer Research News to Cheer About". Parade. Retrieved April 2, 2023.
  5. ^ Anisimov, SI; Kapeliovich, BL; Perelman, TL (February 1974). "Electron emission from metal surfaces exposed to ultrashort laser pulses" (PDF). Soviet Physics JETP. 39 (2).
  6. ^ Ilev, Ilko K.; Boppart, Stephen A.; Andersson-Engels, Stefan; Kim, Beop-Min; Perelman, Lev; Tuchin, Valery (March 2014). "Introduction to the issue on biophotonics". IEEE Journal of Selected Topics in Quantum Electronics. 20 (2): 4–7. Bibcode:2014IJSTQ..20....4I. doi:10.1109/JSTQE.2014.2313622. ISSN 1558-4542.
  7. ^ Qiu, Le; Zhang, Lei; Turzhitsky, Vladimir; Khan, Umar; Zakharov, Yuri; Kantekure, Kanchan; Vitkin, Edward; Itzkan, Irving; Pleskow, Douglas K.; Sawhney, Mandeep; Berzin, Tyler M.; Goldsmith, Jeffrey D.; Perelman, Lev T. (2019). "Multispectral Endoscopy with Light Gating for Early Cancer Detection". IEEE Journal of Selected Topics in Quantum Electronics. 25 (1): 7201309. Bibcode:2019IJSTQ..2554608Q. doi:10.1109/JSTQE.2018.2854608. ISSN 1077-260X. PMC 6594557. PMID 31244520.
  8. ^ Perelman, L. T.; Backman, V.; Wallace, M.; Zonios, G.; Manoharan, R.; Nusrat, A.; Shields, S.; Seiler, M.; Lima, C.; Hamano, T.; Itzkan, I.; Van Dam, J.; Crawford, J. M.; Feld, M. S. (January 19, 1998). "Observation of Periodic Fine Structure in Reflectance from Biological Tissue: A New Technique for Measuring Nuclear Size Distribution". Physical Review Letters. 80 (3): 627–630. Bibcode:1998PhRvL..80..627P. doi:10.1103/PhysRevLett.80.627.
  9. ^ Wallace, Michael B.; Perelman, Lev T.; Backman, Vadim; Crawford, James M.; Fitzmaurice, Marianne; Seiler, Maurice; Badizadegan, Kamran; Shields, Steven J.; Itzkan, Irving; Dasari, Ramachandra R.; Van Dam, Jacques; Feld, Michael S. (September 1, 2000). "Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy". Gastroenterology. 119 (3): 677–682. doi:10.1053/gast.2000.16511. ISSN 0016-5085. PMID 10982761.
  10. ^ Qiu, Le; Pleskow, Douglas K.; Chuttani, Ram; Vitkin, Edward; Leyden, Jan; Ozden, Nuri; Itani, Sara; Guo, Lianyu; Sacks, Alana; Goldsmith, Jeffrey D.; Modell, Mark D.; Hanlon, Eugene B.; Itzkan, Irving; Perelman, Lev T. (May 2010). "Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus". Nature Medicine. 16 (5): 603–606. doi:10.1038/nm.2138. ISSN 1546-170X. PMC 3052700. PMID 20383155.
  11. ^ a b Backman, V.; Wallace, M. B.; Perelman, L. T.; Arendt, J. T.; Gurjar, R.; Müller, M. G.; Zhang, Q.; Zonios, G.; Kline, E.; McGillican, T.; Shapshay, S.; Valdez, T.; Badizadegan, K.; Crawford, J. M.; Fitzmaurice, M. (July 2000). "Detection of preinvasive cancer cells". Nature. 406 (6791): 35–36. doi:10.1038/35017638. ISSN 1476-4687. PMID 10894529. S2CID 4383575.
  12. ^ Gurjar, Rajan S.; Backman, Vadim; Perelman, Lev T.; Georgakoudi, Irene; Badizadegan, Kamran; Itzkan, Irving; Dasari, Ramachandra R.; Feld, Michael S. (November 2001). "Imaging human epithelial properties with polarized light-scattering spectroscopy". Nature Medicine. 7 (11): 1245–1248. doi:10.1038/nm1101-1245. ISSN 1546-170X. PMID 11689891. S2CID 10756302.
  13. ^ Georgakoudi, Irene; Sheets, Ellen E.; Müller, Markus G.; Backman, Vadim; Crum, Christopher P.; Badizadegan, Kamran; Dasari, Ramachandra R.; Feld, Michael S. (March 1, 2002). "Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo". American Journal of Obstetrics and Gynecology. 186 (3): 374–382. doi:10.1067/mob.2002.121075. ISSN 0002-9378. PMID 11904594.
  14. ^ Sokolov, Konstantin; Drezek, Rebekah; Gossage, Kirk; Richards-Kortum, Rebecca (1999). "Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology". Optics Express. 5 (13). Optica Publishing Group: 302–317. Bibcode:1999OExpr...5..302S. doi:10.1364/oe.5.000302. PMID 19401735. Retrieved April 3, 2023.
  15. ^ Zhang, Lei; Pleskow, Douglas K.; Turzhitsky, Vladimir; Yee, Eric U.; Berzin, Tyler M.; Sawhney, Mandeep; Shinagare, Shweta; Vitkin, Edward; Zakharov, Yuri; Khan, Umar; Wang, Fen; Goldsmith, Jeffrey D.; Goldberg, Saveli; Chuttani, Ram; Itzkan, Irving (March 13, 2017). "Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy". Nature Biomedical Engineering. 1 (4): 1–7. doi:10.1038/s41551-017-0040. ISSN 2157-846X. PMC 5646377. PMID 29057146.
  16. ^ Pogue, Brian W.; Wang, Kenneth K. (April 12, 2017). "Cancer diagnostics: Light scattering by pancreatic cysts". Nature Biomedical Engineering. 1 (4): 1–2. doi:10.1038/s41551-017-0060. ISSN 2157-846X. S2CID 90919028.
  17. ^ Pleskow, Douglas K.; Sawhney, Mandeep S.; Upputuri, Paul K.; Berzin, Tyler M.; Coughlan, Mark F.; Khan, Umar; Glyavina, Maria; Zhang, Xuejun; Chen, Liming; Sheil, Conor J.; Cohen, Jonah M.; Vitkin, Edward; Zakharov, Yuri N.; Itzkan, Irving; Zhang, Lei (January 7, 2023). "In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy". Nature Communications. 14 (1): 109. Bibcode:2023NatCo..14..109P. doi:10.1038/s41467-022-35780-7. ISSN 2041-1723. PMC 9825389. PMID 36611024.
  18. ^ Itzkan, Irving; Qiu, Le; Fang, Hui; Zaman, Munir M.; Vitkin, Edward; Ghiran, Ionita C.; Salahuddin, Saira; Modell, Mark; Andersson, Charlotte; Kimerer, Lauren M.; Cipolloni, Patsy B.; Lim, Kee-Hak; Freedman, Steven D.; Bigio, Irving; Sachs, Benjamin P. (October 30, 2007). "Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels". Proceedings of the National Academy of Sciences. 104 (44): 17255–17260. Bibcode:2007PNAS..10417255I. doi:10.1073/pnas.0708669104. ISSN 0027-8424. PMC 2077242. PMID 17956980.
  19. ^ Cassiday, Laura (January 1, 2008). "Bio Sphere: A first CLASS microscope". Analytical Chemistry. 80 (1): 29. doi:10.1021/ac085998b. ISSN 0003-2700.
  20. ^ Pettinato, Giuseppe; Coughlan, Mark F.; Zhang, Xuejun; Chen, Liming; Khan, Umar; Glyavina, Maria; Sheil, Conor J.; Upputuri, Paul K.; Zakharov, Yuri N.; Vitkin, Edward; D’Assoro, Antonino B.; Fisher, Robert A.; Itzkan, Irving; Zhang, Lei; Qiu, Le (August 20, 2021). "Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids". Science Advances. 7 (34): eabj2800. Bibcode:2021SciA....7.2800P. doi:10.1126/sciadv.abj2800. ISSN 2375-2548. PMC 8373132. PMID 34407934.
  21. ^ Melo, Sonia A.; Sugimoto, Hikaru; O’Connell, Joyce T.; Kato, Noritoshi; Villanueva, Alberto; Vidal, August; Qiu, Le; Vitkin, Edward; Perelman, Lev T.; Melo, Carlos A.; Lucci, Anthony; Ivan, Cristina; Calin, George A.; Kalluri, Raghu (November 10, 2014). "Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis". Cancer Cell. 26 (5): 707–721. doi:10.1016/j.ccell.2014.09.005. ISSN 1535-6108. PMC 4254633. PMID 25446899.
  22. ^ Kneipp, Katrin; Wang, Yang; Kneipp, Harald; Perelman, Lev T.; Itzkan, Irving; Dasari, Ramachandra R.; Feld, Michael S. (March 3, 1997). "Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)". Physical Review Letters. 78 (9): 1667–1670. Bibcode:1997PhRvL..78.1667K. doi:10.1103/PhysRevLett.78.1667.
  23. ^ Itzkan, I; Albagli, D; Dark, M L; Perelman, L T; von Rosenberg, C; Feld, M S (March 14, 1995). "The thermoelastic basis of short pulsed laser ablation of biological tissue". Proceedings of the National Academy of Sciences. 92 (6): 1960–1964. Bibcode:1995PNAS...92.1960I. doi:10.1073/pnas.92.6.1960. ISSN 0027-8424. PMC 42402. PMID 7892208.
  24. ^ Marshall, John; Adcroft, Alistair; Hill, Chris; Perelman, Lev; Heisey, Curt (March 15, 1997). "A finite-volume, incompressible Navier Stokes model for studies of the ocean on parallel computers". Journal of Geophysical Research: Oceans. 102 (C3): 5753–5766. Bibcode:1997JGR...102.5753M. doi:10.1029/96JC02775.
  25. ^ Marshall, John; Hill, Chris; Perelman, Lev; Adcroft, Alistair (March 15, 1997). "Hydrostatic, quasi-hydrostatic, and nonhydrostatic ocean modeling". Journal of Geophysical Research: Oceans. 102 (C3): 5733–5752. Bibcode:1997JGR...102.5733M. doi:10.1029/96JC02776.
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