Postcibalome is the comprehensive array of biochemical and physiological responses that occur in the body, most notably in the blood, following the consumption of food.[1] This term encompasses the complex interplay of hormonal, nutritional, and metabolic changes that take place as the body processes food and returns to its fasting state.[citation needed] It includes fluctuations in hormones, nutrients, metabolites, and proteins, as well as stress responses associated with excessive food intake. The term "postcibalome" is derived from "postcibal," which combines the prefix "post-" (after) with the Latin word "cibus," meaning food.[citation needed]
The changes in blood composition after eating are intricate and can serve as important indicators of metabolic health.[2] Studies have shown that alterations in glucose and insulin levels are significant markers of metabolic dysfunction, with insulin resistance often signifying a risk for diabetes.[3] Additionally, the gene expression and proteome of white blood cells, as well as the metabolome and proteome of the blood, exhibit dynamic changes in response to food intake.[citation needed] These collective fluctuations highlight the body's adaptive mechanisms in managing nutrient intake and maintaining metabolic balance.[citation needed]
References
edit- ^ Dordevic, Aimee L.; Williamson, Gary (2023). "Systematic Review and Quantitative Data Synthesis of Peripheral Blood Mononuclear Cell Transcriptomics Reveals Consensus Gene Expression Changes in Response to a High Fat Meal". Molecular Nutrition and Food Research. 67 (23): 2300512. doi:10.1002/mnfr.202300512. PMID 37817369.
- ^ Kardinaal, Alwine F. M.; Erk, Marjan J.; Dutman, Alice E.; Stroeve, Johanna H. M.; Steeg, Evita; Bijlsma, Sabina; Kooistra, Teake; Ommen, Ben; Wopereis, Suzan (2015). "Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health". FASEB J. 29 (11): 4600–4613. doi:10.1096/fj.14-269852. PMID 26198450.
- ^ Kahn (2006). "Mechanisms linking obesity to insulin resistance and type 2 diabetes". Nature. 444 (7121): 840–846. Bibcode:2006Natur.444..840K. doi:10.1038/nature05482. PMID 17167471.
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