Drežnica may refer to:
- Drežnica, Croatia, a village near Ogulin, Croatia
- Drežnica, Serbia, a village near Bujanovac, Serbia
- Drežnica, Slovenia, a village near Kobarid, Slovenia
- Donja Drežnica, a village near Mostar, Bosnia and Herzegovina
- Gornja Drežnica, a village near Mostar, Bosnia and Herzegovina
- Drežnica, one of the largest karst vales in Bosnia and Herzegovina and the Balkans, and the river Drežanka (sometimes Drežnica), right tributary of the Neretva,