Duchess of Abercorn is typically a title of the wife of the Duke of Abercorn, and may refer to:
- Louisa Hamilton, Duchess of Abercorn (1812–1905), wife of the 1st Duke
- Mary Hamilton, Duchess of Abercorn (1848–1929), wife of the 2nd Duke
- Rosalind Hamilton, Duchess of Abercorn (1869–1958), wife of the 3rd Duke
- Kathleen Hamilton, Duchess of Abercorn (1905–1990), wife of the 4th Duke
- Alexandra Hamilton, Duchess of Abercorn (1946–2018), wife of the 5th Duke