NFIL3

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.

NFIL3
Identifiers
Aliases	NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A, nuclear factor, interleukin 3 regulated
External IDs	OMIM: 605327; MGI: 109495; HomoloGene: 3928; GeneCards: NFIL3; OMA:NFIL3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.31 Start 91,409,045 bp End 91,423,832 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 B1|13 27.68 cM Start 53,121,245 bp End 53,135,109 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava pericardium gastric mucosa left uterine tube cartilage tissue popliteal artery tibial arteries stromal cell of endometrium periodontal fiber right ventricle Top expressed in muscle of thigh gastrula granulocyte zygote primary oocyte secondary oocyte digastric muscle left lobe of liver plantaris muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding transcription corepressor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding Cellular component nucleus Biological process cellular response to interleukin-4 positive regulation of gene expression regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II circadian rhythm immune response transcription, DNA-templated rhythmic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4783 18030 Ensembl ENSG00000165030 ENSMUSG00000056749 UniProt Q16649 O08750 RefSeq (mRNA) NM_005384 NM_001289999 NM_001290000 NM_017373 RefSeq (protein) NP_001276928 NP_001276929 NP_005375 NP_059069 Location (UCSC) Chr 9: 91.41 – 91.42 Mb Chr 13: 53.12 – 53.14 Mb PubMed search
Wikidata
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Function

Expression of interleukin-3 (IL-3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.

Further reading

• Cowell IG, Skinner A, Hurst HC (July 1992). "Transcriptional repression by a novel member of the bZIP family of transcription factors". Molecular and Cellular Biology. 12 (7): 3070–7. doi:10.1128/mcb.12.7.3070. PMC 364521. PMID 1620116.
• Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. doi:10.1128/mcb.15.11.6055. PMC 230857. PMID 7565758.
• Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Cowell IG, Hurst HC (September 1996). "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids Research. 24 (18): 3607–13. doi:10.1093/nar/24.18.3607. PMC 146135. PMID 8836190.
• Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT (March 1997). "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2609–14. Bibcode:1997PNAS...94.2609I. doi:10.1073/pnas.94.6.2609. PMC 20136. PMID 9122243.
• Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (June 2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis". Human Genetics. 106 (6): 594–6. doi:10.1007/s004390000306. PMID 10942106.
• Ozkurt IC, Tetradis S (July 2003). "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts". The Journal of Biological Chemistry. 278 (29): 26803–9. doi:10.1074/jbc.M212652200. PMID 12743120.
• Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD (June 2006). "Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells". Biochemical and Biophysical Research Communications. 344 (2): 491–9. doi:10.1016/j.bbrc.2006.03.169. PMC 2763529. PMID 16630563.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.