Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene.[5][6]

ESM1
Identifiers
AliasesESM1, endocan, endothelial cell specific molecule 1
External IDsOMIM: 601521; MGI: 1918940; HomoloGene: 5107; GeneCards: ESM1; OMA:ESM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007036
NM_001135604

NM_023612

RefSeq (protein)

NP_001129076
NP_008967

NP_076101

Location (UCSC)Chr 5: 54.98 – 55.02 MbChr 13: 113.35 – 113.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals.[6]

The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan / ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as vascular endothelial growth factor (VEGF) or fibroblast growth factor 2 (FGF-2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan / ESM-1.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164283Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042379Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lassalle P, Molet S, Janin A, Heyden JV, Tavernier J, Fiers W, Devos R, Tonnel AB (Oct 1996). "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines". J Biol Chem. 271 (34): 20458–64. doi:10.1074/jbc.271.34.20458. PMID 8702785.
  6. ^ a b "Entrez Gene: ESM1 endothelial cell-specific molecule 1".

Further reading

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