Eastern Macedonia may refer to:
- eastern parts of the geographical and historical region of Macedonia (region)
- Pirin Macedonia, the part of the region of Macedonia in Bulgaria
- Eastern Macedonia and Thrace, an administrative region in Greece
- Eastern Statistical Region, a statistical region in modern North Macedonia
- eastern parts of the ancient Kingdom of Macedonia
- eastern parts of the ancient Roman Province of Macedonia
- Eastern Macedonia Army Section, an army group of the Hellenic Army in World War II
- Technological Educational Institute of Eastern Macedonia and Thrace, an institute in Kavala, Greece