Ent-kaurenoic acid oxidase (EC 1.14.13.79) is an enzyme with systematic name ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction
| Ent-kaurenoic acid oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.79 | ||||||||
| CAS no. | 337507-95-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ent-kaur-16-en-19-oate + 3 NADPH + 3 H+ + 3 O2 gibberellin A12 + 3 NADP+ + 4 H2O (overall reaction)
- (1a) ent-kaur-16-en-19-oate + NADPH + H+ + O2 ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
- (1b) ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + H+ + O2 gibberellin A12 aldehyde + NADP+ + 2 H2O
- (1c) gibberellin A12 aldehyde + NADPH + H+ + O2 gibberellin A12 + NADP+ + H2O
Ent-kaurenoic acid oxidase requires cytochrome P450.
References
edit- ^ Helliwell CA, Chandler PM, Poole A, Dennis ES, Peacock WJ (February 2001). "The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 2065–70. doi:10.1073/pnas.041588998. PMC 29382. PMID 11172076.
External links
edit- Ent-kaurenoic+acid+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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