Eastern Region or East Region may refer to:
- Eastern Region (Abu Dhabi): Al Ain
- Eastern Region, Ghana
- Eastern Region (Iceland)
- Eastern Region, Malta
- Eastern Region, Nepal
- Eastern Region, Nigeria
- Eastern Region, Serbia
- Eastern Region, Uganda
- Eastern Region of British Railways
- AAA Eastern Region, a high school sports region of large high schools in the state of Virginia
- Eastern Region Women's Football League, England
- Eastern Region (Northern Ireland football)
- East Region (Cameroon)
- East Region, Singapore
- Est Region, Burkina Faso
- Purvanchal (lit. 'eastern region'), a region of India
- East Punjab (state), former state in northwestern India (1947–1966), the eastern part of the Punjab region
- Punjab, India, a state of India divided from the above, sometimes still referred to as East Punjab