The ERRs are orphan nuclear receptors , meaning the identity of their endogenous ligand has yet to be unambiguously determined. They are named because of sequence homology with estrogen receptors, but do not appear to bind estrogens or other tested steroid hormones.
There are three human estrogen related receptors
ERRs bind enhancers throughout the genome where they exert effects on gene regulation. The ERR family exhibit varying transcriptional activation capabilities and physically interact with the transcriptional co-activators PGC1-alpha and PGC1-beta,[ 1] [ 2] [ 3] [ 4] [ 5] [ 6] [ 6] [ 7] [ 1] [ 8] [ 1] [ 9] [ 10] [ 11] [ 12] [ 13] [ 14] [ 15] [ 16] [ 17] [ 2] cancer .[ 18] [citation needed
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