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Étienne de Harven

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Etienne de Harven (1928-2019) was a Belgian-born pathologist and electron microscopist. Born in Brussels, he did most of his work in New York City, Paris and Toronto.[citation needed] He did pioneering research on viruses, mostly related to murine leukemia.[2] He is former President of the Electron Microscopy Society of America (now Microscopy Society of America).[3][4]

Etienne de Harven
BornMarch 5, 1928
Brussels, Belgium
DiedMarch 6, 2019
Alma materUniversité Libre de Bruxelles
AwardsRik et Nel Wouters Award (1969), presented by Queen Fabiola of Belgium for Cancer Research.[1] President of the Electron Microscopy Society of America in 1976
Scientific career
FieldsPathology, electron microscopy, cancer research
InstitutionsMemorial Sloan-Kettering Cancer Center (1956-1981), University of Toronto (1981-1993) Cornell Graduate School
Academic advisorsCharles Oberling, Wilhelm Bernhard

Biography and Work

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De Harven obtained his medical degree from the University of Brussels.[1] He later worked at the Institute of Cancer of Villejuif under Charles Oberling and Wilhelm Bernhard, where he made pioneering observations of the structure of centrioles.[5]

He was subsequently hired by Memorial Sloan-Kettering Cancer Center, where he worked alongside Charlotte Friend and studied viruses, mostly in mice systems[6] and the causation and incidence of leukemia[7] and other malignant diseases related to those viruses.[8][9] Later, he provided the first description of a viral budding.[10] While at Sloan-Kettering, de Harven was part of a team which discovered "virus-like particles" in cells taken from patients with Hodgkin's disease.[11] He became professor of cell biology at the University of Cornell and later of pathology at the University of Toronto, where he researched the marking of antigens on the surface of lymphocytes.[12][13]

As former President of the Microscopy Society of America, he published several papers, mostly related to Cancer Pathologies and electron microscopy procedures for viral explorations.[14]

De Harven was a prominent skeptic of the scientific validity of the link between HIV and AIDS,[15] one of a group invited in 2000 to South Africa by president Thabo Mbeki to serve on a presidential panel on AIDS.[16][17] He published a book in 2005 entitled Les Dix Plus Gros Mensonges sur le SIDA (Ten Lies About AIDS),[citation needed] in which he denies a connection between the HIV virus and AIDS, instead attributing the disease to lifestyle and environmental factors.[18]

De Harven died in 2019.[19]

References

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  1. ^ a b "Gerry Ann Schramm Married Here to Dr. Etienne de Harven". New York Times. 26 April 1970. p. 82.
  2. ^ De Harven, E; Friend, C (1966). "Origin of the viremia in murine leukemia". National Cancer Institute Monograph. 22: 79–105. PMID 4288573.
  3. ^ Photos of Past Presidents of the Microscopy Society of America (Former "Electron Microscopy Society of America") - Etienne de Harven (1976) - http://www.microscopy.org/about/past_presidents_photos.cfm#1976
  4. ^ List of Past Presidents of the Microscopy Society of America - Etienne de Harven (1976): http://www.microscopy.org/about/past_presidents.cfm
  5. ^ Vorobjev, I. A.; Nadezhdina, E. S. (1987). The Centrosome and Its Role in the Organization of Microtubules. International Review of Cytology. Vol. 106. pp. 227–293. doi:10.1016/S0074-7696(08)61714-3. ISBN 978-0-12-364506-7. PMID 3294718.. See also de Harven's own recollections of this work: de Harven, Etienne (1994). "Early observations of centrioles and mitotic spindle fibers by transmission electron microscopy" (PDF). Biology of the Cell. 80 (2–3): 107–109. doi:10.1111/j.1768-322X.1994.tb00916.x. PMID 8087058. S2CID 84594630. Archived from the original (PDF) on 2014-09-12. Retrieved 2011-10-16..
  6. ^ Sato, Toru; Friend, Charlotte; de Harven, Etienne (1971). "Ultrastructural Changes in Friend Erythroleukemia Cells Treated with Dimethyl Sulfoxide". Cancer Research. 31 (10): 1402–17. PMID 4106212.
  7. ^ De Tkaczevski, L; De Harven, E; Friend, C (1968). "Structure and leukemogenic activity of a murine leukemia virus". Journal of Virology. 2 (4): 365–75. doi:10.1128/JVI.2.4.365-375.1968. PMC 375622. PMID 5742040.
  8. ^ De Harven, E. (1958). "Electron Microscope Study of a Cell-Free Induced Leukemia of the Mouse: A Preliminary Report". The Journal of Cell Biology. 4 (2): 151–6. doi:10.1083/jcb.4.2.151. PMC 2224333. PMID 13525427.
  9. ^ Friend, Charlotte; Darchun, Violet; De Harven, Etienne; Haddad, Jamil (2008). "The Incidence and Classification of Spontaneous Malignant Diseases of the Haematopoietic System in Swiss Mice". Ciba Foundation Symposium - Tumour Viruses of Murine Origin. Novartis Foundation Symposia. pp. 193–213. doi:10.1002/9780470719275.ch10. ISBN 978-0-470-72271-8.
  10. ^ De Harven, E. (1960). "Further Electron Microscope Studies of a Mouse Leukemia Induced by Cell-Free Filtrates". The Journal of Cell Biology. 7 (4): 747–52. doi:10.1083/jcb.7.4.747. PMC 2224877. PMID 13814781.
  11. ^ "Cancer Cells Yield Virus-Like Particles". New York Times. 10 September 1971. p. 18.
  12. ^ Harven, E.; Soligo, D.; Christensen, H. (1990). "Double labelling of cell surface antigens with colloidal gold markers". The Histochemical Journal. 22 (1): 18–23. doi:10.1007/BF01962875. PMID 1690186. S2CID 11630704.
  13. ^ McGroarty, RJ; Mills, GB; De Harven, E (1990). "Immunogold labeling of the low-affinity (55 kd) IL2 receptor on the surface of IL2 receptor-bearing cultured cells and mitogen-activated peripheral blood lymphocytes". Journal of Leukocyte Biology. 48 (3): 213–9. doi:10.1002/jlb.48.3.213. PMID 2391447. S2CID 23382096.
  14. ^ De Harven, E. (1977). "Electron Microscopy: Remarks on 40 Years Of Ultrastructural Explorations". CA: A Cancer Journal for Clinicians. 27 (5): 281–288. doi:10.3322/canjclin.27.5.281. PMID 411549.
  15. ^ Aberth, John (2010). Plagues in World History. Rowman & Littlefield. p. 143. ISBN 978-0-7425-5705-5..
  16. ^ Rohleder, Poul; Swartz, Leslie; Kalichman, Seth C. (2009). HIV/AIDS in South Africa 25 years on: psychosocial perspectives. Springer. p. 125. ISBN 978-1-4419-0305-1..
  17. ^ Kalichman, Seth C. (2009). Denying AIDS: conspiracy theories, pseudoscience, and human tragedy. Springer. pp. 61, 128, 180. ISBN 978-0-387-79475-4..
  18. ^ De Harven, Etienne, Ten Lies about Aids, Trafford Publishing, 2008
  19. ^ Rethinking AIDS, the most important HIV/AIDS denialist group, announces Professor De Harven's passing away: http://rethinkingaids.com/index.php/etienne-de-harven-1928-2019
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