Excitatory amino acid transporter 4

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.

SLC1A6
Identifiers
Aliases	SLC1A6, EAAT4, solute carrier family 1 member 6
External IDs	OMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.12 Start 14,950,033 bp End 15,022,990 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C1|10 39.72 cM Start 78,616,330 bp End 78,650,599 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum endothelial cell left testis right testis paraflocculus of cerebellum skin of thigh cerebellar vermis nucleus accumbens oocyte caudate nucleus Top expressed in cerebellar vermis lobe of cerebellum dorsomedial hypothalamic nucleus lumbar subsegment of spinal cord ventromedial nucleus inferior colliculi superior colliculus dentate gyrus of hippocampal formation granule cell lateral hypothalamus ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function L-aspartate transmembrane transporter activity symporter activity L-glutamate transmembrane transporter activity amino acid transmembrane transporter activity high-affinity glutamate transmembrane transporter activity metal ion binding Cellular component integral component of membrane Golgi apparatus membrane intermediate filament cytoskeleton integral component of plasma membrane plasma membrane glutamatergic synapse integral component of presynaptic membrane Biological process chemical synaptic transmission regulation of membrane potential ion transport glutamate secretion aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate import across plasma membrane amino acid transport L-aspartate transmembrane transport neurotransmitter uptake transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6511 20513 Ensembl ENSG00000105143 ENSMUSG00000005357 UniProt P48664 O35544 RefSeq (mRNA) NM_001272087 NM_001272088 NM_005071 NM_001384669 NM_001384670 NM_001384671 NM_009200 RefSeq (protein) NP_001259016 NP_001259017 NP_005062 NP_033226 Location (UCSC) Chr 19: 14.95 – 15.02 Mb Chr 10: 78.62 – 78.65 Mb PubMed search
Wikidata
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EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.

Further reading

• Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839. S2CID 42347750.
• Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
• Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4". J. Physiol. 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917.
• Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047. S2CID 4381210.
• Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044. S2CID 30779935.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824. S2CID 4420825.